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Wanida Visuthipanich. Histochemical and pathological changes in rat gastric mucosa following Aloe vera gel and cortisol administrations. Master's Degree(Anatomy). Mahidol University. Mahidol University Library and Knowledge Center. : Mahidol University, 1988.
Histochemical and pathological changes in rat gastric mucosa following Aloe vera gel and cortisol administrations
การเปลี่ยนแปลงทางเนื้อเยื่อวิทยา และพยาธิสภาพของเยื่อบุผิวกระเพาะอาหารในหนูที่เกิดขึ้นจากการกินวุ้นว่านหางจระเข้ และจากการฉีดคอร์ติซอล
Name: Wanida Visuthipanich
LCSH:
Aloe
LCSH:
Epithelium
LCSH:
Gastric Mucosa
LCSH:
Hydrocortisone
LCSH:
Stomach Ulcer
Abstract:
Histopathological and histochemical changes after 1/2, 1, 3, and 7 days of cortisol (COL), Aloe Vera gel (AG), and combined COL and AG administrations on the gross appearance, the pattern of distribution and intensity of staining of the mucosubstances in the various epithelial components of the rat corpus and antral mucosa as well as the thickness of these parameters were investigated. COL (10 mg/100 g, bw, sc, bid) administrations alone produced severe multiple erosions in the corpus at 7 days while AG (5 mg/100 g bw, po, bid) alone had no effect, and the group of rats treated with both COL and AG contained some ulcers in the corpus but at a slightly lesser degree of severity. As revealed by the Alcian blue pH2.5-periodic acid-Schiff and Hematoxylene and Eosin stained sections, 5 µ, hemorrhagic erosions with some leukocytic infiltration and evidence of necrosis at the bed and peripery of the lesioned site. The thickness of the corpus surface epithelium and foveolar cells as well as the intensity of staining of the mucosubstances of the surface epithelium and the apical portion (isthmus) of the corpus glands were greatly diminished following COL, particularly at 7 days following the threatments. On the other hand, AG seemed to act specifically and mainly at the deeper portion of the glandular tissue of the corpus to promote the synthesis and release of the (acidic mucus predominating) mucosubstances. The ulcer-producing effect of COL and the ulcer-healing effect of AG were discussed in relation to these changes.
Mahidol University. Mahidol University Library and Knowledge Center
Address:
NAKHONPATHOM
Email:
liwww@mahidol.ac.th
Name: Chatchai Trakulrungsi
Role:
Thesis Advisors
Name: Witaya Thamavit
Role:
Thesis Advisors
Created:
1988
Modified:
2018-09-14
Issued:
2018-09-14
วิทยานิพนธ์/Thesis
application/pdf
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Anatomy
Grantor: Mahidol University
ใช้เวลา
0.404386 วินาที
Wanida Visuthipanich
| Title | Contributor | Type |
|---|---|---|
| Histochemical and pathological changes in rat gastric mucosa following Aloe vera gel and cortisol administrations
มหาวิทยาลัยมหิดล Wanida Visuthipanich | Chatchai Trakulrungsi Witaya Thamavit | วิทยานิพนธ์/Thesis |
Chatchai Trakulrungsi
Witaya Thamavit