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Wandee Sirapat. Behavioral and neurobiochemical effects of chronic exposure to low dose of paraquat in rats. Master's Degree(Toxicology). Mahidol University. Mahidol University Library and Knowledge Center. : Mahidol University, 1993.
Behavioral and neurobiochemical effects of chronic exposure to low dose of paraquat in rats
ผลของพาราควอทต่อพฤติกรรมของสัตว์และระดับสารชีวเคมีในระบบประสาท เมื่อได้รับสารในปริมาณน้อยเป็นเวลานานในหนูขาว
Name: Wandee Sirapat
MeSH:
Nervous system
MeSH:
Behavior, Animal
Abstract:
The neurotoxic effects of chronic exposure to subcutaneous administration of low dose of paraquat on the motor behaviors and the alterations of the neurotrasmitter levels(dopamine, norepinephrine, 5-hydroxytryptamine and its metabolites, 5-hydroxyindoleacetic acid) in various brain regions of male, Wistar rats were studied. Subcutaneous administration of paraquat 1, 2 and 3 mg/kg, 5 days per week for 8 weeks altered the total ambulatory and stereotypic activities in 20 minutes recorded by the open-field test. These alterations were dose- and time-dependent. There were no other obvious toxic effects of paraquat observed. The rotational behaviors were determined in the paraquat-treated groups as compare to control. It was found that there was no alteration in this motor behavior. In addition, the levels of dopamine in both paraquat-treated and control were not significantly different. The chronic exposure to 3-mg/kg dose of paraquat results in the significant lower body weight, motor performance and the norepinephrine levels in the hypothalamus as compare to control. The less body weight in paraquat-treated group as compare to control group may be related to the decreases in norepinephrine levels in the hypothalamus, which was previously suggested to have some role i n feed ing control. Hypothalamus appeared to be the area, among various discrete brain areas, that paraquat can easily pass into the brain due to its insufficient blood-brain barrier. The results of this study indicated that chronic exposure to paraquat can induce the neurotoxic effects with no detectable dopaminergic damage in the striatum, and there may be some noradrenergic system disturbance in the hypothalamus. The open-field test is one of the most sensitive method that can detect the adverse effects of paraquat at low doses. Further studies are needed to elucidate the specific sites and mechanisms of paraquat induced the decreases in motor behavioral activities.
Mahidol University. Mahidol University Library and Knowledge Center
Address:
NAKHONPATHOM
Email:
liwww@mahidol.ac.th
Name: Jutamaad Satayavivad
Role:
Thesis Advisors
Name: Yupin Sanvarinda
Role:
Thesis Advisors
Name: Udom Chantharaksri
Role:
Thesis Advisors
Created:
1993
Modified:
2561-02-16
Issued:
2018-02-14
วิทยานิพนธ์/Thesis
application/pdf
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Toxicology
Grantor: Mahidol University
©copyrights Mahidol University
RightsAccess:
ใช้เวลา
-0.575822 วินาที
Wandee Sirapat
| Title | Contributor | Type |
|---|---|---|
| Behavioral and neurobiochemical effects of chronic exposure to low dose of paraquat in rats
มหาวิทยาลัยมหิดล Wandee Sirapat | Jutamaad Satayavivad Yupin Sanvarinda Udom Chantharaksri | วิทยานิพนธ์/Thesis |
Jutamaad Satayavivad
| Title | Creator | Type and Date Create |
|---|---|---|
| Behavioral and neurobiochemical effects of chronic exposure to low dose of paraquat in rats
มหาวิทยาลัยมหิดล Jutamaad Satayavivad ;Yupin Sanvarinda;Udom Chantharaksri | Wandee Sirapat | วิทยานิพนธ์/Thesis |
Yupin Sanvarinda
Udom Chantharaksri