A study of prevalence of macula pigment optical density reduction in type 2 diabetes mellitus patients

Study of prevalence of macula pigment optical density reduction in type 2 diabetes mellitus patients

Name: Khin, Hnin Le

Organization : Mae Fah Luang University

keyword: Macula pigment

LCSH: Retinal Diseases

Classification :.LCCS: WW270

LCSH: Macula Lutea

LCSH: Diabetes Mellitus

Abstract: Oxidative stress is known to be an exacerbating factor in some retinal diseases, e.g. reduction of MPOD in age-related macular degeneration. Thus this study was designed to investigate the prevalence of macular pigment optical density (MPOD) reduction in Type 2 diabetes mellitus patients in Thailand. Eighty-two patients of both males and females, age 30-60 years with type 2 diabetes mellitus were recruited to this study. Macular Pigment Screener II (MPSII) was used to measure the macula pigment density level of the volunteers. The participants completed a self-administrative questionnaire to the various physical, ocular, life-style, dietary and environmental factors that may be possibly associated with MPOD. If there were no previous laboratory measurements within a week of this research, Glycosylated haemoglobin (HbA1c), Fasting Blood Sugar (FBS) and serum lipid profile were taken after 8 hours of night fasting. Observational, descriptive analytic study and correlation study were used. The mean absolute MP of type 2 diabetes mellitus patients was 0.37 ± 0.22. Among 82 participants of type 2 diabetes mellitus, 61% (n=50) had the MPOD value of < 0.43 DU. No significant correlations were found between MPOD and FBS, HbA1c, duration of diabetes mellitus or serum lipid levels. There was significant association between Absolute MP value and concurrent history of having Hypertension (χ2=5.304, p value=0.021). There was significant correlation between absolute MP value and Age (r=0.262, p value=0.017) that shows the Absolute MP value and increasing age are positively related. There were no significant correlations with other several parameters. In conclusions, mean MPOD in diabetic subjects were found to be lower than the normal people. Of the 82 subjects recruited into this study, the prevalence of 61% had MPOD value lower than normal level. This indicated that there was lower level of MPOD in type 2 diabetes patients than normal Thailand subjects.

Mae Fah Luang University

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Karnt Wongsuphasawat

Role: Advisor

Created: 2016

Issued: 2560

Modified: 2020-04-29

Issued: 2017-09-04

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis WW270 K456s 2016

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Anti-Aging and Regenerative Medicine

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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