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Pathom Somwong. Phytochemistry and bioactivities of salacia verrucosa and ficus foveolata stems. Doctoral Degree(Pharmacognosy). Chulalongkorn University. Office of Academic Resources. : Chulalongkorn University, 2012.
Phytochemistry and bioactivities of salacia verrucosa and ficus foveolata stems
พฤกษเคมีและฤทธิ์ทางชีวภาพของลำต้นตากวางและม้ากระทืบโรง
Name: Pathom Somwong
LCSH:
Botanical chemistry
LCSH:
Celastraceae
LCSH:
Moraceae
LCSH:
Cancer
Abstract:
hemical investigation of the stems of Salacia verrucosa Wight (family Celastraceae) led to the isolation of one new (21α-hydroxyfriedelane-1,3-dione) and three known 1,3-diketofriedelane triterpenes (friedelane-1,3-dione, 26-hydroxyfriedelane-1,3-dione and 30-hydroxyfriedelane-1,3-dione), three friedelane-type triterpenes (friedelin, kokoonol and 21α-hydroxyfriedelan-3-one), and one oleanane-type triterpene (3β,22α-dihydroxyolean-12-en-29-oic acid). From the stems of Ficus foveolata (Wall. ex Miq.) Miq. (family Moraceae), two new (foveolide A and foveoeudesmenone) and two known eudesmane-type sesquiterpenes [4(15)-eudesmene-1β,6α-diol and 4(15)-eudesmene-1β,5α-diol], a new sesquiterpenoid dimer (foveolide B), one new (foveospirolide) and one known phenolic compound (ethyl rosmarinate), together with three known triterpenes (friedelin, taraxerol and betulin) were isolated. The chemical structures of these plant constituents were determined by spectroscopic analyses, including UV, IR, MS and NMR, and comparison with previously reported data. Friedelane-1,3-dione was strongly cytotoxic against human colon cancer cell line (SW620) with an IC [subscript 50] value of 2.02 µM, whereas 26-hydroxyfriedelane-1,3-dione and 21α-hydroxyfriedelan-3-one were moderately cytotoxic against colon, liver (HepG2) and gastric (KATO-III) cancer cell lines. 26-Hydroxyfriedelane-1,3-dione also exhibited moderate cytotoxicity against lung (CHAGO) and breast (BT474) cancer cell lines. Foveolide A was moderately cytotoxic against colon, liver, breast and gastric cancer cell lines, while foveolide B was specifically cytotoxic toward colon cancer cell line. In addition, foveolide A exhibited anti-tuberculosis activity against Mycobacterium tuberculosis with a minimum inhibitory concentration of 200 µM.
Abstract:
hemical investigation of the stems of Salacia verrucosa Wight (family Celastraceae) led to the isolation of one new (21α-hydroxyfriedelane-1,3-dione) and three known 1,3-diketofriedelane triterpenes (friedelane-1,3-dione, 26-hydroxyfriedelane-1,3-dione and 30-hydroxyfriedelane-1,3-dione), three friedelane-type triterpenes (friedelin, kokoonol and 21α-hydroxyfriedelan-3-one), and one oleanane-type triterpene (3β,22α-dihydroxyolean-12-en-29-oic acid). From the stems of Ficus foveolata (Wall. ex Miq.) Miq. (family Moraceae), two new (foveolide A and foveoeudesmenone) and two known eudesmane-type sesquiterpenes [4(15)-eudesmene-1β,6α-diol and 4(15)-eudesmene-1β,5α-diol], a new sesquiterpenoid dimer (foveolide B), one new (foveospirolide) and one known phenolic compound (ethyl rosmarinate), together with three known triterpenes (friedelin, taraxerol and betulin) were isolated. The chemical structures of these plant constituents were determined by spectroscopic analyses, including UV, IR, MS and NMR, and comparison with previously reported data. Friedelane-1,3-dione was strongly cytotoxic against human colon cancer cell line (SW620) with an IC [subscript 50] value of 2.02 µM, whereas 26-hydroxyfriedelane-1,3-dione and 21α-hydroxyfriedelan-3-one were moderately cytotoxic against colon, liver (HepG2) and gastric (KATO-III) cancer cell lines. 26-Hydroxyfriedelane-1,3-dione also exhibited moderate cytotoxicity against lung (CHAGO) and breast (BT474) cancer cell lines. Foveolide A was moderately cytotoxic against colon, liver, breast and gastric cancer cell lines, while foveolide B was specifically cytotoxic toward colon cancer cell line. In addition, foveolide A exhibited anti-tuberculosis activity against Mycobacterium tuberculosis with a minimum inhibitory concentration of 200 µM.
Chulalongkorn University. Office of Academic Resources
Address:
BANGKOK
Email:
cuir@car.chula.ac.th
Name: รุทธ์ สุทธิศรี
Role:
advisor
Name: Rutt Suttisri
Role:
advisor
Created:
2012
Modified:
2016-02-27
Issued:
2016-02-27
วิทยานิพนธ์/Thesis
application/pdf
URL: http://cuir.car.chula.ac.th/handle/123456789/44824
eng
DegreeName: Doctor of Philosophy
Level: Doctoral Degree
Descipline: Pharmacognosy
Grantor: Chulalongkorn University
©copyrights Chulalongkorn University
RightsAccess:
ใช้เวลา
0.044367 วินาที
Pathom Somwong
| Title | Contributor | Type |
|---|---|---|
| Phytochemistry and bioactivities of salacia verrucosa and ficus foveolata stems
จุฬาลงกรณ์มหาวิทยาลัย Pathom Somwong | รุทธ์ สุทธิศรี Rutt Suttisri | วิทยานิพนธ์/Thesis |
| Isolation, Purification and Quantitative determination of Asiaticoside, Madecassoside, Asiatic acid and Madecassic acid in Varieties of Centella Asiatica (L.) URB.
จุฬาลงกรณ์มหาวิทยาลัย Pathom Somwong | Chamnan Patarapanich Suwanna Laungchonlatan | วิทยานิพนธ์/Thesis |
| Research Report Research Project chemical constituents and cytotoxicity of clerodendrum indicum and clerodendrum villosum roots
มหาวิทยาลัยรังสิต Pathom Somwong | Research Institute of Rangsit University | งานวิจัย/Research report |
รุทธ์ สุทธิศรี
| Title | Creator | Type and Date Create |
|---|---|---|
| Phytochemistry and bioactivities of salacia verrucosa and ficus foveolata stems
จุฬาลงกรณ์มหาวิทยาลัย ;รุทธ์ สุทธิศรี;Rutt Suttisri | Pathom Somwong | วิทยานิพนธ์/Thesis |
Rutt Suttisri