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Narissara Kaprasob. Preparation and charecterization of sodium carboxymethyl cellulose, chitosan and polyacrylamide hydrogels for controlled drug release. Master's Degree(Polymer Science). Burapha University. Library. : Burapha University, 2015.
Preparation and charecterization of sodium carboxymethyl cellulose, chitosan and polyacrylamide hydrogels for controlled drug release
Name: Narissara Kaprasob
keyword:
Hydrogel
Abstract:
The interpenetrating polymer network (IPN) hydrogels of sodium
carboxymethyl cellulose/polyacrylamide (NaCMC/PAAm) and chitosan/
polyacrylamide (CS/PAAm) were prepared and characterized for the application of
drug delivery system. The hydrogels containing different homopolymer compositions
(1:2, 1:1 and 2:1) were crosslinked with citric acid and N,N'-methylenebisacrylamide
(MBAAm). These hydrogels were studied in terms of gel content, swelling,
morphology and thermal stability. Drug loading capacity and release properties of
hydrogels were investigated. The results from gel fraction (%) and ATR-FTIR
analysis indicated that the hydrogels were successfully prepared and crosslinked. The
effect of pH on the swelling ratio was studied. It was found that the swelling ratio of
NaCMC/PAAm hydrogels was high in pH7 and 10 solutions. The values increased
with increasing NaCMC content. The highest swelling ratio of 144 was measured
from NaCMC/PAAm (2:1) in pH7 solution. In the case of CS/PAAm hydrogels, the
highest swelling ratio of 8 was measured from CS/PAAm (1:2) hydrogel in pH2
solution. To evaluate the possibility of hydrogels for an application of drug delivery
system, the NaCMC/PAAm and CS/PAAm hydrogels were loaded with positively
and negatively charged model drugs, crystal methyl violet (MV) and methyl orange
(MO), respectively. It was found that NaCMC composition of the hydrogel played an
important role in MV loading capacity in that the loading increased with increasing
NaCMC composition. The CS/PAAm hydrogels were loaded with MO and tested for
the encapsulation capacity. It was found that the loading was initially rapid and the
equilibrium was reached after 30 min. The anti-inflammatory drugs, DS and IBU, were also used for the investigation of release behavior. The release of IBU from
NaCMC/PAAm hydrogel under SIF conditions was slower and lesser than that of the
DS which could be due to the low solubility of IBU in release condition. The release
efficiency of DS and IBU from CS/PAAm hydrogels was investigated in SGF
medium. The prolonged releases of DS and IBU were observed within 72 h of
investigation period.
As described above, the hydrogels based on NaCMC/PAAm and
CS/PAAm could be used as candidates for the development of drug delivery device.
These systems demonstrated a potential application in the field of drug carrier based
on interaction between drug and hydrogel and based on pH at certain location in the
body.
Burapha University. Library
Address:
CHONBURI
Email:
buulibrary@buu.ac.th
Role:
Principal advisor
Name: Piyaporn Na Nongkhai
Role:
Co-advisor
Created:
2015
Modified:
2564-11-15
Issued:
2015-10-26
วิทยานิพนธ์/Thesis
application/pdf
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Polymer Science
Grantor: Burapha University
ใช้เวลา
0.023032 วินาที
Narissara Kaprasob
| Title | Contributor | Type |
|---|---|---|
| Preparation and charecterization of sodium carboxymethyl cellulose, chitosan and polyacrylamide hydrogels for controlled drug release
มหาวิทยาลัยบูรพา Narissara Kaprasob | Thanida Trakulsujaritchock Piyaporn Na Nongkhai | วิทยานิพนธ์/Thesis |
Thanida Trakulsujaritchock
| Title | Creator | Type and Date Create |
|---|---|---|
| Chemically modofied poly (styrene-co-divinyl benzene-co-vinylbenzyl chloride) by click reaction and its magnetic nano-composites = preparation, characterization, and adsorption properties
มหาวิทยาลัยบูรพา Thanida Trakulsujaritchock;Piyaporn Na Nongkhai | Songwut Lapwanit | วิทยานิพนธ์/Thesis |
| Preparation and charecterization of sodium carboxymethyl cellulose, chitosan and polyacrylamide hydrogels for controlled drug release
มหาวิทยาลัยบูรพา Thanida Trakulsujaritchock;Piyaporn Na Nongkhai | Narissara Kaprasob | วิทยานิพนธ์/Thesis |
| Preparation and characterization of poly [Methacrylic acid-ran-2methacryloyloxyethyl phosphorylcholine] Copolymer coated magnetite nanoparticles for biosensor application
มหาวิทยาลัยบูรพา Piyaporn Na Nongkhai;Thanida Trakulsujaritchock | Supannika Boonjamnian | วิทยานิพนธ์/Thesis |
Piyaporn Na Nongkhai