Chemical constituents of garcinia cowa, and their antibacterial and antioxidation properties

Name: Ngampuk Tayana

Organization : Mae Fah Luang University

keyword: Garcinia cowa

LCSH: Garcinia

Classification :.LCCS: QK898.B54

Abstract: Phytochemical investigation from the roots of Garcinia cowa resulted in the isolation of forty-four compounds; macluraxanthone (RAG1), formoxanthone C (RAG2), cochinchinone C (RAG3), calophymembranol B (RAG4), dulxanthone B (RAG5), b-mangostin (RAG6), cochinchinone G (RAG7), 10-O-methylmaclura-xanthone (RAG8), cochinchinone A (RAG9), cowaxanthone (RAG10), euxanthone (RAG11), 6-hydroxy-1,2,3,7-tetramethoxyxanthone (RAG12), stigmasterol (RAG13), α-mangostin (RAG14), isocudraniaxanthone B (RAG15), xanthone V1 (RAG16), cowanin (RAG17), cowanol (RAG18), pyranojacareubin (RAG19), 9,10-dihydroxy-5-methoxy-12-(1,1-dimethyl-2-propenyl)-2H,6H-pyrano[3,2-b]xanthen-6- one (RAG20), 1,5,7-trihydroxy-3-methoxyxanthone (RAG22), norathyriol (RAG23), 7-geranyloxy-1,3-dihydroxyxanthone (RAG24), gartanin (RAG25), morusignin I (RAG26), parvixanthone B (RAG27), 1,3,7-trihydroxy-2-(3-methyl-2-butenyl) xanthone (RAG28), 5-O-methylxanthone V1 (RAG29), friedelin (RAG30), lupenone (RAG31), lupane (RAG32), damnacanthal (RAG33), 2,3-dihydroxy-1-methoxylanthraquinone (RAG34), cochinchinone E (RAG35), 1,3,6-trihydroxy-7- methoxy-2,5-bis(3-methyl-2-butenyl)xanthone (RAG36), β-sitosterol (RAG37), kaempferol (RAG38), assiguxanthone B (RAG40), 1,6-dihydroxy-5- methoxyxanthone (RAG41), 3,4-dihydro-6,11-dihydroxy-2,2-dimethyl-pyrano[3,2-c]-xanthene-7(2H)-one (RAG42), morelloflavone (RAG43), cowagarcinone B (RAG44), 6-hydroxy-2,3-dimethoxyxanthone (RMG1), and assiguxanthone A (RMG2). Their structures were elucidated by spectroscopic analysis. Thirty compounds (RAG1-RAG5, RAG7-RAG9, RAG12, RAG15-RAG16, RAG19-RAG20, RAG22, RAG24-RAG29, RAG31-RAG35, RAG40-RAG42, and RMG1-RMG2) were reported for the first time as metabolites of G. cowa. Some isolated compounds were further evaluated for their antibacterial and antioxidation activities. Compound RAG14 was found to show a strong antibacterial activities against B. cereus and MRSA-SK1with MIC value of 0.5 g/mL, which were better than that of vancomycin (MIC 1 g/mL). Three isolated compounds RAG6, RAG17, and RAG18 exhibited strong antibacterial activities against B. cereus, MRSA-SK1, S. aureus, and E. coli with MICs range of 0.5-4 g/mL. Compounds RAG7, RAG15, RAG20, and RAG24 showed strong antibacterial activity against E. coli with MIC value of 8 μg/mL, In addition, the results of antioxidation activities of isolated compounds RAG1, RAG2, RAG15, RAG16, and RAG38 were expressed at IC50 values of 35.86 ± 0.15, 35.55 ± 0.43, 19.75 ± 0.39, 19.70 ± 0.39, and 11.67 ± 0.12 μM, respectively whereas ascorbic acid showed IC50 value of 2.10 ± 0.01 μM.

Mae Fah Luang University. The Learning Resources and Education Media Center

Address: Chiang Rai

Email: library@mfu.ac.th

Name: Suwanna Deachathai

Role: Advisor

Name: Siripat Suteerapataranon

Role: Co-Advisor

Name: Sarin Sriprang

Role: Co-Advisor

Created: 2014

Issued: 2015

Modified: 2020-04-03

Issued: 2015-10-16

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis QK898.B54 N576c 2014

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Applied Chemistry

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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