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Porntipa Pankongadisak. Development of silver nanoparticles-loaded alginate beads embedded in gelatin scaffolds for wound dressing applications. Master's Degree(Materials Science). Mae Fah Luang University . : Mae Fah Luang University , 2013.
Development of silver nanoparticles-loaded alginate beads embedded in gelatin scaffolds for wound dressing applications
Name: Porntipa Pankongadisak
Organization :
Mae Fah Luang University
keyword:
Nanoparticles-loaded
Classification :.LCCS: Silver
Classification :.;: Nanoparticles
;
Silver
Classification :.;: Wound Healing
Abstract:
Wound infection is a main problem for wound healing process that caused from bacterial infection. From this problem, wound dressing is developed by incorporating an antibacterial agent which has an activity to kill bacteria. Silver nanoparticles (AgNPs) are mostly used as antibacterial agents that have strong antibacterial activity for using in small amount. In this research, the AgNPs-loaded alginate beads embedded in gelatin scaffolds were fabricated for use as wound dressings. The AgNPs-loaded calcium alginate beads were obtained by either electrospraying or emulsification/external gelation method. The silver (Ag+
) ions in alginate solution reduced to AgNPs were prepared by UV irradiation technique. The size and shape of beads were observed using optical microscope (OM) and scanning electron microscope (SEM). Gelatin scaffolds were fabricated from 5% w/v of gelatin solution and crosslinked with genipin. The AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were fabricated by freeze-drying method. The morphology, mechanical properties and thermal properties of these scaffolds were characterized by SEM, universal testing machine (UTM) and thermogravimetric analysis (TGA), respectively. Moreover, these scaffolds were investigated for their water swelling and weight loss behaviors in the phosphate buffer solution (PBS) at 37 oC for 1, 3, 5 and 7 days. The release characteristics of Ag+ ions from both the AgNPs-loaded calcium alginate beads and the AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were carried out in either deionized water (DI) or PBS
at 37 oC for 7 days. Lastly, the AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were tested for their cytotoxicity and antibacterial activity.
Mae Fah Luang University
Address:
CHIANG RAI
Email:
library@mfu.ac.th
Name: Orawan Suwantong
Role:
Advisor
Role:
Co-Advisor
Created:
2013
Modified:
2020-03-30
Issued:
2015-02-16
วิทยานิพนธ์/Thesis
application/pdf
CallNumber:
Thesis QT36.5 P836d 2013
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Materials Science
Grantor: Mae Fah Luang University
©copyrights Mae Fah Luang University
RightsAccess:
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Porntipa Pankongadisak
| Title | Contributor | Type |
|---|---|---|
| Development of silver nanoparticles-loaded alginate beads embedded in gelatin scaffolds for wound dressing applications
มหาวิทยาลัยแม่ฟ้าหลวง Porntipa Pankongadisak | วิทยานิพนธ์/Thesis | |
| Thermoresponsive hydrogels and electrospun fibers for delivery of therapeutic agents
มหาวิทยาลัยแม่ฟ้าหลวง Porntipa Pankongadisak | Orawan Suwantong | วิทยานิพนธ์/Thesis |
Orawan Suwantong
Uracha Rungsardthong Ruktanonchai
| Title | Creator | Type and Date Create |
|---|