Phalakorn Suebsomran. Association between alcohol consumption and type 2 diabetes mellitus : a case-control study. Master's Degree(Epidemiology ). Mahidol University. : Mahidol University, 2009.
Association between alcohol consumption and type 2 diabetes mellitus : a case-control study
Abstract:
This study is a population-based, matched case-control study which was
conducted between March 2007 and September 2008, to determine the relationship
between alcohol consumption and type 2 diabetes mellitus (T2DM). Data were
collected by means of questionnaires and patients medical records. Subjects included
470 cases of newly diagnosed T2DM and 470 healthy controls living in the
communities in Roi-Et Province, Thailand. For each case, a control was selected and
matched for gender, age (within 5 years) and community of residence.
A multivariate analysis with control of confounding factors showed that
alcohol consumption was significantly related to T2DM. Current-drinkers were more
likely to have T2DM when compared to non-drinkers (odds ratio [OR] and 95%
confidence interval [CI] of 2.4 [1.3 to 4.2, p < 0.001]). Various aspects of alcohol
consumption supported this relationship. These aspects included duration of drinking
(> 25 years, OR [95% CI] compared to non-drinkers of 3.9 [1.5 to 10.6]; 19-25 years,
3.1 [1.3 to 7.6]; 2-18 years, 2.0 [1.1 to 3.7]), frequency of drinking (3-7 days/week, 2.6
[1.3 to 5.1]; 1-2 days/week, 1.9 [0.9 to 3.9]; 1 day/week or less, 2.6 [1.1 to 6.0]),
amount of alcohol per week (> 142 gm, 4.6 [2.0 to 10.5]; 66.01-142 gm, 2.2 [1.0 to
4.6]; ≤ 66 gm, 2.1 [1.1 to 4.0]), and lifetime cumulative dose of alcohol (> 185,327
gm, 4.4 [1.8 to 10.6]; 48,935.01-185,327 gm, 2.5 [1.1 to 5.5]; ≤ 48,935, 2.0 [1.1 to
3.8]). The model adjusted for blood pressure, physical activity, BMI, family history
and smoking. There were no significant interactions between various co-factors and
alcohol consumption regarding the risk of T2DM.
These data suggested that alcohol consumption may be an important risk factor
for the development of type 2 diabetes mellitus.