Effects of different oil types and surfactant concentrations on the physical stability of nanoemulsions and In Vitro release of Diclofenac-loaded nanoemulsions

Name: Ei Ei Maw

MeSH: Emulsions -- stability

MeSH: Nanoemulsions -- stability

MeSH: Surfact Active Agents

MeSH: Drugs -- controlled release

Abstract: In this study, formation of oil in water nanoemulsions in oil/non-ionic surfactant/water has been produced by a high pressure homogenization technique. Four different kinds of oil (mineral oil, soybean oil, Eutanol G and Myritol 318) and three concentrations of surfactant (5%, 7.5% and 10%) were studied. The ratio of non-ionic surfactant (Brij 721 and Brij 72) used was 3:1. A decrease in droplet size was observed through three homogenization cycles at a pressure of 200 bar and a temperature of 75°C. All nanoemulsions were found to possess a small size, around 168-233 nm. It was revealed that the different physicochemical properties of oils (polarity, solubility and chemical structure), surfactant concentrations and storage temperature had an effect on Ostwald ripening rate. Both conventional emulsion and nanoemulsion formulations maintained stability for 4 months storage at room temparature and 45°C, except the formulations that were prepared using Myritol 318 as the oil phase. Moreover, it was also found that conventional emulsion of Eutanol G with 5% surfactant concentration at 45°C showed Ostwald ripening rate. The formulations containing mineral oil and soybean oil as the oil phase did not exhibit droplet growth during storage for 4 months, which showed that it was stable to Ostwald ripening because of low extremely water solubility of these oils. An emulsion system composed of diclofenac acid and diclofenac sodium was characterized in terms of in vitro drug release. The release profiles of conventional emulsions and nanoemulsions were not significantly different since their particle sizes were comparable. The in vitro release rate showed that the release of drugs from both conventional emulsions and nanoemulsions depended on the polarity of oil and oil/water partition coefficient. It was also observed that the high surfactant concentration retarded the release of both drugs due to the formation of thick multilayer of surfactants around the oil droplets. When comparing release profiles between lipophilic and hydrophilic drugs from nanoemulsions, it was noticed that the hydrophilicity of oil plays an important role in drug release.

Mahidol University

Address: NAKHON PATHOM

Email: liwww@mahidol.ac.th

Name: Varaporn Junyaprasert

Role: Thesis Advisors

Created: 2007

Modified: 2553-06-22

Issued: 2010-06-12

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: TH E34e 2007

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Pharmaceutics

Grantor: Mahidol University

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