The application of nutraceuticals as alternative to antibiotic growth promoters on oxidative stress, inflammatory status and gut health of broiler under various stresses

Name: Kittisak Insawake

LCSH: Kasetsart University -- Dissertations. Ph.D. (Animal Nutrition and Feed Technology) 2023

Classification :.LCCS: SF498.7

LCSH: Kasetsart University. -- Department of Animal Science -- Dissertations

LCSH: Broilers (Chickens) -- Feeding and feeds

LCSH: Antibiotic growth promoters

LCSH: Feed additives

Abstract: Broilers raised under intensive commercial production are faced with a variety of stresses, potentially from management, environment, and nutrition, which impair growth performance and health. Three experiments were conducted to investigate the effects of flavanones (FVN) and isoquinoline alkaloids (IQA) supplementation as alternatives to antibiotic growth promoters (AGPs) in broilers raised under high stock density, natural heat stress, and the exposure to low dose of aflatoxin-contaminated feed. Experiment 1 was conducted in broilers to compare the effects of high stock density (15 birds/m2) and normal stocking density (10 birds/m2). Raising broilers under high stock density caused a negative effect on growth performance, oxidative stress, inflammatory status and gut health. Results indicated that the supplementation of 300 ppm FVN or 80 ppm IQA showed the same efficacy as 50 ppm bacitracin (AGPs) in alleviating all negative effects caused by high stock density. Experiment 2 was conducted in broilers to study the effects of high stock density (15 birds/m2) in combination with natural heat stress. Similar to that of AGPs, the supplementation of 300 ppm FVN or 80 ppm IQA throughout the experiment and a combination of FVN-IQA or IQA-FVN supplementation (during starter-the rest) improved growth performance, inflammatory status, and gut health of broilers. Moreover, when 300 ppm FVN was supplemented during starter period, a promising reduction in oxidative stress of the broiler was observed. Experiment 3 was conducted to study the effects of feeding aflatoxin-contaminated diet (50 ppb) to broilers raised under a combination of high stock density (18 birds/m2) and natural heat stress. The exposure to 50 ppb aflatoxin-contaminated diet impaired growth performance, oxidative stress, inflammatory status and gut health of broilers. The supplementation of 300 ppm FVN or 80 ppm IQA alleviated all negative effects. In addition, feeding a combination of FVN-IQA and IQA-FVN (during starter-the rest) showed a favorable effect on duodenum and jejunum histology under complex stresses. The results from these experiments clearly indicated that FVN and IQA are effective in improving growth performance and mitigating health problems of broiler under complex stresses. Therefore, they could be potentially used as alternative to AGPs for modern commercial broiler production

Kasetsart University. Office of the University Library

Address: Bangkok

Email: tdckulib@ku.ac.th

Name: Yuwares Ruangpanit

Role: Thesis Advisor

Name: Thaweesak Songserm

Role: Thesis CO-Advisor

Name: Chainarong Rattanakreetakul

Role: Thesis CO-Advisor

Name: Ornprapan Songserm

Role: Thesis CO-Advisor

Created: 2023

Modified: 2026-06-19

Issued: 2026-06-19

วิทยานิพนธ์/Thesis

application/pdf

URL: https://kasetsart.idm.oclc.org/login?url=https://www.lib.ku.ac.th/KUthesis/2566/kittisak-insa-all.pdf

CallNumber: SF498.7.K48

eng

DegreeName: Doctor of Philosophy

Level: Doctoral Degree

Descipline: Animal Nutrition and Feed Technology

Grantor: Kasetsart University

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