Experimental study of screen-printed lab-on-a-chip for depressive substance analysis

Name: Warisara Boonsiri

Organization : King Mongkut's University of Technology North Bangkok. Department of Industrial Physics and Medical Instrumentation

Email : mink.warisara@gmail.com

Name: Kessararat Ugsornrat

Organization : King Mongkut's University of Technology North Bangkok. Department of Industrial Physics and Medical Instrumentation

Email : kessararat.u@sci.kmutnb.ac.th

Name: Wichayaporn Kamsong

Organization : King Mongkut's University of Technology North Bangkok. Department of Industrial Physics and Medical Instrumentation

Email : wichayaporn.kam@ncr.nstda.or.th

Name: Chanpen Karuwan

Organization : National Science and Technology Development Agency. Graphene and Printed Electronics for Dual-use Application Research Division

Email : chanpen.kar@nstda.or.th

Name: Assawapong Sappat

Organization : National Science and Technology Development Agency. Graphene and Printed Electronics for Dual-use Application Research Division

Email : assawapong.sap@nstda.or.th

Name: Adisorn Tuantranont

Organization : National Science and Technology Development Agency. Graphene and Printed Electronics for Dual-use Application Research Division

Email : adisorn.tua@nstda.or.th

keyword: Lab-on-a-chip devices

LCSH: Chemical detectors

LCSH: Screen process printing

LCSH: Substance abuse -- Analysis

Abstract: This study presents the development and evaluation of a screen-printed electrowetting-on-dielectric (EWOD) microchip for the electrochemical analysis of depressive substances. The device consists of two integrated components: a T-junction EWOD structure and an electrochemical detection zone. The EWOD module comprises two primary layers a silver electrode and a polydimethylsiloxane (PDMS) dielectric layer fabricated via screen-printing and spin-coating techniques, respectively. At the end of the T-junction, an electrochemical sensor was embedded, consisting of a screen-printed electrode system including a carbon working electrode, a carbon counter electrode, and a silver/silver chloride (Ag/AgCl) reference electrode. All electrodes were fabricated using a layer-by-layer screen-printing method. Cyclic voltammetry was employed to assess the sensor's performance in detecting substances associated with depression. Reverse testing with dopamine a key neurotransmitter linked to depressive disorders yielded voltammograms closely matching a previously established calibration curve. These results highlight the potential of the proposed EWOD-based microchip as a promising platform for portable and reliable depressive substance analysis.

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2025

Modified: 2026-01-07

Issued: 2026-01-07

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BibliograpyCitation : In IEEE Thailand Section. Antennas and Propagation/Electron Devices/Microwave Theory and Techniques Joint Chapter, Electrical Engineering/Electronics, Computer, Telecommunications, and Information Technology Association, and King Mongkut's University of Technology North Bangkok. The 5th Research, Invention and Innovation Congress (RI2C 2025) (pp.173-177). Bangkok : IEEE Thailand Section

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