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Vichugorn Wattayagorn. Inhibitory effect of hydrolyzed Riceberry Rice Bran extract on colon cancer cell lines. Master's Degree(Biology). Kasetsart University. Office of the University Library. : Kasetsart University, 2021.
Inhibitory effect of hydrolyzed Riceberry Rice Bran extract on colon cancer cell lines
Name: Vichugorn Wattayagorn
keyword:
Rice bran Utilization.
Classification :.LCCS: RC269
LCSH:
Cancer cells
LCSH:
Colon (Anatomy)
-- Cancer
LCSH:
Antineoplastic agents
LCSH:
Protein hydrolysates
LCSH:
Cell death
LCSH:
Apoptosis
Abstract:
Riceberry rice bran is the part of rice that has been scrubbed out during the coloring process. There are various health benefits to be gained from foods with a high protein content. This work aimed to study the effect of hydrolyzed riceberry rice bran extracts on colon cancer cell lines compared to normal cells. The MTT assay result showed that our extract has lower cytotoxicity effects on normal cells (PCS201-010, IC50 = 6745 µg/mL) compared to colon cancer cell lines and has a greater effect on metastatic cancer cell lines (SW-620, IC50 = 5468 µg/mL) than nonmetastatic cancer cell lines (HT-29, IC50 = 6054 µg/mL). The apoptotic inductive effects of HRBE on SW-620 were observed after 72 h at a maximum rate of 76% and at maximum concentration. According to the result of the cell senescence analysis after 24 h of HRBE treatment, the percentage of HT-29 (86%) expressing SA-β-gal was much higher than that of SW-620 (32%). Consequently, the decrease in the cell population in the S and M/G2 phases indicated cell cycle arrest in HT-29 cells after being treated with HRBE. Focusing on the peptide fraction size of HRBE, the largest (>50 kDa) fraction showed the highest anticancer activity compared to other fractions. In conclusion, the hydrolyzed riceberry rice bran extract induced the apoptosis process in the metastatic cancer cells and induced the senescence process in the non-metastatic cancer cells. This observed information will be useful and applicable for medical research and colon cancer treatment in the future.
Kasetsart University. Office of the University Library
Address:
Bangkok
Email:
tdckulib@ku.ac.th
Name: Mesayamas Kongsema
Role:
Thesis Advisor
Name: Pramote Chumnanpuen
Role:
Thesis CO-Advisor
Created:
2021
Modified:
2025-07-20
Issued:
2025-07-20
วิทยานิพนธ์/Thesis
application/pdf
URL: https://www.lib.ku.ac.th/KUthesis/2564/vichugorn-wat-all.pdf
CallNumber:
RC269 .V53
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Biology
Grantor: Kasetsart University
©copyrights Kasetsart University
RightsAccess:
ใช้เวลา
0.018282 วินาที
Vichugorn Wattayagorn
| Title | Contributor | Type |
|---|---|---|
| Inhibitory effect of hydrolyzed Riceberry Rice Bran extract on colon cancer cell lines
มหาวิทยาลัยเกษตรศาสตร์ Vichugorn Wattayagorn | Mesayamas Kongsema | วิทยานิพนธ์/Thesis |
Mesayamas Kongsema
| Title | Creator | Type and Date Create |
|---|---|---|
| The biological effect of cordyceps militaris powder extract on HT29 and SW620 colon cancer cell lines
มหาวิทยาลัยเกษตรศาสตร์ Mesayamas Kongsema | Atchariya Pomjunya | วิทยานิพนธ์/Thesis |
| Inhibitory effect of thiostrepton and its nano encapsulation on breast cancer cell lines
มหาวิทยาลัยเกษตรศาสตร์ Mesayamas Kongsema | Sudtirak Wongkhieo | วิทยานิพนธ์/Thesis |
| Comparative sperm proteomics in Thai Swamp Buffalo (Bubalus bubalis) with different freezabiligy
มหาวิทยาลัยเกษตรศาสตร์ Mesayamas kongsema | Thunchanok Wilasri | วิทยานิพนธ์/Thesis |
| Hybrid nanocarrier (nanostructured lipid carriers-in-pH responsive microsphere) for oral targeted delivery against Colorectal cancer
มหาวิทยาลัยเกษตรศาสตร์ Mesayamas Kongsema | Atitaya Phasuk | วิทยานิพนธ์/Thesis |
| Inhibitory effect of hydrolyzed Riceberry Rice Bran extract on colon cancer cell lines
มหาวิทยาลัยเกษตรศาสตร์ Mesayamas Kongsema | Vichugorn Wattayagorn | วิทยานิพนธ์/Thesis |
Pramote Chumnanpuen