Development of a PSMA-11 lyophilized kit for convenient radiolabeling with 68Ga

Name: Boon-Uma Jowanaridhi

Organization : Thailand Institute of Nuclear Technology (Public Organization). Radioisotope Center

Email : boonuma@tint.or.th

Name: Thidarat Kohud

Organization : Thailand Institute of Nuclear Technology (Public Organization). Radioisotope Center

Name: Kanyapat Lumyong

Organization : Thailand Institute of Nuclear Technology (Public Organization). Radioisotope Center

Name: Suppamat Makjan

Organization : Thailand Institute of Nuclear Technology (Public Organization). Radioisotope Center

Name: Chonticha Phaophang

Organization : Thailand Institute of Nuclear Technology (Public Organization). Radioisotope Center

Name: Sudkanung Phumkem

Organization : Thailand Institute of Nuclear Technology (Public Organization). Radioisotope Center

keyword: Prostate-specific membrane antigen (PSMA)

LCSH: Radiopharmaceuticals

; Gallium-68

LCSH: Freeze-drying

LCSH: Diagnostic imaging

LCSH: Radiolabeling

LCSH: Cancer -- Diagnosis

Abstract: Prostate specific membrane antigen (PSMA) targeting ligands labeled with various types of radionuclides have been developed and used for diagnosis of prostate cancer. The positron-emitting radionuclide gallium-68 (68Ga) produced from a 68Ge/68Ga generator has an excellent advantage in terms of on-site synthesis. It is similar in principle to 99Mo/99mTc generator which makes the cold kits for 99mTc radiolabeling become widely used in medical imaging. 68Ga-PSMA-11 has been increasingly used in Thailand since 2017. This radiopharmaceutical is often produced by commercial synthesis modules which have high consumable costs and require hot cell facilities. While the kit-based production has advantages of lower cost, shorter preparation time and easier to operate. The aim of this work was to develop the PSMA-11 kit in a form of lyophilized powder to be ready for radiolabel with 68Ga. The lyophilization process was performed under sterile conditions. The kit could be radiolabeled with 5–20 mCi of 68Ga at room temperature in 15 min. The radiopharmaceutical 68Ga-PSMA-11 produced from the kit had high radiochemical purity without purification and was stable for at least 4 h. The biological quality control showed that the lyophilized product was a sterile, nonpyrogenic kit. It could be said that, by using the PSMA-11 kit, the production of 68Ga-PSMA-11 was relatively easy, cost effective and radiologically safe

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2024

Modified: 2024-12-09

Issued: 2024-12-09

บทความ/Article

application/pdf

BibliograpyCitation : In Kasetsart University. Faculty of Science. The Pure and Applied Chemistry International Conference 2024 (PACCON 2024) (pp.914-918). Bangkok : Kasetsart University, 2024

eng

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