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Chutima Jiarpinitnun. Syntheses of curcumin derivatives and their biological activity against Staphylococcus aureus. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2024.
Syntheses of curcumin derivatives and their biological activity against Staphylococcus aureus
Name: Krit Ruechai
Organization :
Mahidol University. Faculty of science
Name: Chutima Jiarpinitnun
Organization :
Mahidol University. Faculty of science
Email :
chutima.jia@mahidol.ac.th
keyword:
Curcumin derivatives
LCSH:
Curcumin
LCSH:
Staphylococcus aureus
LCSH:
Anti-infective agents
Abstract:
Biofilm formation is considered one of the most serious health concerns. It could lead to an infection
that could be lethal. In the biofilm state, biofilm provide a shelter to protect bacteria from being eradicated by
antibiotics, leading to drug resistance development. Several anti-biofilm-forming strategies were established.
Disruption of bacterial adhesion is one of the alternative methods to avoid biofilm formation at the beginning
step, particularly during the initial step that planktonic cells need to attach to a surface. In this work, we
investigate the antibacterial activity of curcumin and derivatives against Staphylococcus aureus, which has a
cysteine transpeptidase enzyme that plays a significant role in the bacterial adhesion, formation and
maintenance of biofilms. Due to the Michael addition of enone functional group of curcumin and derivatives
that possibly irreversible covalent bond with sulfhydryl group of cysteine, our hypothesis was that these
substances might have antimicrobial properties. A total of four curcumin derivatives and one non-conjugated
derivative were subjected to susceptibility assays and biofilm formation against S. aureus. We discovered that
curcumin could inhibit bacterial growth activity against S. aureus, which shows a clear inhibition zone of 8.64
± 0.18 mm. Moreover, these derivatives exhibited anti-biofilm activities in micromolar range. Among these
derivatives, compound 2B was the most potent anti-biofilm agent, with IC50 of 41.12 μM
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2024
Modified:
2024-12-04
Issued:
2024-12-04
บทความ/Article
application/pdf
BibliograpyCitation :
In Kasetsart University. Faculty of Science. The Pure and Applied Chemistry International Conference 2024 (PACCON 2024) (pp.825-829). Bangkok : Kasetsart University, 2024
eng
©copyrights King Mongkut's University of Technology North Bangkok
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0.027067 วินาที
Krit Ruechai
| Title | Contributor | Type |
|---|---|---|
| Syntheses of curcumin derivatives and their biological activity against Staphylococcus aureus
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Krit Ruechai;Chutima Jiarpinitnun | บทความ/Article |
Chutima Jiarpinitnun
| Title | Contributor | Type |
|---|---|---|
| Design and synthesis of small molecules for arsenic detection
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Suphawit Phonpho;Chutima Jiarpinitnun | บทความ/Article | |
| Antibacterial activities of vinyl sulfones and carbonylacrylic derivatives against oral bacteria
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| Modulate gram-negative biofilm formation with synthetic small molecules
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| Syntheses of pinostrobin derivatives and their inhibitory activities of cystic fibrosis transmembrane conductance regulator (CFTR)
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| Design and synthesis of trimethoprim derivatives for MRSA therapeutics
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| Inhibition of Staphylococcus aureus biofilm formation by natural coumarins
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| Syntheses of curcumin derivatives and their biological activity against Staphylococcus aureus
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Krit Ruechai;Chutima Jiarpinitnun | บทความ/Article |