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Warangkana Pornputtapitak. Optimization of nanostructured lipid carrier using box-behnken design and its potential use as lignin carrier system. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2024.
Optimization of nanostructured lipid carrier using box-behnken design and its potential use as lignin carrier system
Name: Krittin Intaraopart
Organization :
Mahidol University Nakhon Pathom. Faculty of Engineering
Name: Suthida Boonsith
Organization :
Mahidol University Nakhon Pathom. Faculty of Engineering
Organization :
Mahidol University Nakhon Pathom. Faculty of Engineering
Email :
Warangkana.por@mahidol.edu
keyword:
Nanostructured lipid carriers
LCSH:
Lignin
LCSH:
Drug delivery systems
LCSH:
Nanotechnology
Abstract:
Lignin is a natural polymer that has UV protection potential for sunscreen. However, lignin can cause
irritation to the skin if applied at high concentration. Therefore, nanostructured lipid carriers (NLCs) were
used in this work to reduce the irritation and prolong the UV protection efficiency. This study focuses on the
optimization of lignin- loaded NLCs by using experimental designs including PlackettBurman (PBD) and
Box-Behnken design (BBD) . PBD was studied first to investigate three significant variables among five
variables in which affected the quality of NLCs. Then, BBD was applied to find the optimum condition for
producing NLCs formulation. The results showed that the most affected variables were sonication time,
amplitude of sonication, and lipid concentration, whereas surfactant to lipid and solid to liquid lipid ratio had
less effect on the particle size of the NLCs compared to the others. These three variables were used as
independent variables for BBD. A 50:50 ratio of cetyl palmitate and caprylic/capric triglyceride and a 50:50
ratio of tween 80 and span 40 were used as solid to liquid lipid ratio and co- surfactants, respectively. The
optimum condition showed the smallest NLCs particle size of 95. 9 ± 1.3 nm at time of 5 min 48 seconds,
amplitude of 56%, and lipid concentration of 1.2%. The size was slightly decreased to 85.3 ± 0.86 nm after
loading lignin in the NLCs. In conclusion, PBD and BBD are significant tools for the experimental design to
find the optimal condition by reducing the number of experiments
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2024
Modified:
2024-12-02
Issued:
2024-12-02
บทความ/Article
application/pdf
BibliograpyCitation :
In Kasetsart University. Faculty of Science. The Pure and Applied Chemistry International Conference 2024 (PACCON 2024) (pp.520-523). Bangkok : Kasetsart University, 2024
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.032201 วินาที
Krittin Intaraopart
| Title | Contributor | Type |
|---|---|---|
| Optimization of nanostructured lipid carrier using box-behnken design and its potential use as lignin carrier system
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Krittin Intaraopart;Suthida Boonsith;Warangkana Pornputtapitak | บทความ/Article |
Suthida Boonsith
| Title | Contributor | Type |
|---|---|---|
| Development and optimization of spray-dried kaffir lime peel essential oil microparticles using emulsion stabilized by modified cassava starch
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Nipaporn Rungjitvaranont;Rattiya Tangratniyom;Sirapat Jitanawasan;Suthida Boonsith | บทความ/Article | |
| Optimization of nanostructured lipid carrier using box-behnken design and its potential use as lignin carrier system
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Krittin Intaraopart;Suthida Boonsith;Warangkana Pornputtapitak | บทความ/Article | |
| Development and characterization of amidated pectin-PVA hydrogels for enhanced drug delivery and antimicrobial properties
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Supatcha Suankhem;Woranart Jonglertjunya;Warangkana pornputtapitak;Suthida Boonsith | บทความ/Article | |
| Inhibitory effects of Schinus terebinthifolia leave extract on polyphenol oxidase activity and enzymatic browning
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Supatcha Suankhem;Suthida Boonsith;Warangkana Pornputtapitak | บทความ/Article | |
| Preparation of pectin-based hydrogels from pomelo waste for the delivery of chlorhexidine
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Nattarika Peaunbida ;Warangkana Pornputtapitak;Worawan Tiatragoon;Suthida Boonsith | บทความ/Article | |
| Pickering emulsions of kaffir lime oil stabilized by modified tapioca starch Impact of particle size reduction methods and octenyl succinic anhydride grafting
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Nuttida Kamboon.;Sukanya Thepwatee.;Suthida Boonsith. | บทความ/Article |
Warangkana Pornputtapitak
| Title | Contributor | Type |
|---|---|---|
| Phase behavior of solid-liquid lipid mixtures by coarse-grained molecular dynamics simulations
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Yenruedee Thiangjit;Yuthana Tantirungrotechai;Warangkana Pornputtapitak | บทความ/Article | |
| Optimization of nanostructured lipid carrier using box-behnken design and its potential use as lignin carrier system
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Krittin Intaraopart;Suthida Boonsith;Warangkana Pornputtapitak | บทความ/Article | |
| Development and characterization of amidated pectin-PVA hydrogels for enhanced drug delivery and antimicrobial properties
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Supatcha Suankhem;Woranart Jonglertjunya;Warangkana pornputtapitak;Suthida Boonsith | บทความ/Article | |
| Inhibitory effects of Schinus terebinthifolia leave extract on polyphenol oxidase activity and enzymatic browning
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Supatcha Suankhem;Suthida Boonsith;Warangkana Pornputtapitak | บทความ/Article | |
| Preparation of pectin-based hydrogels from pomelo waste for the delivery of chlorhexidine
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Nattarika Peaunbida ;Warangkana Pornputtapitak;Worawan Tiatragoon;Suthida Boonsith | บทความ/Article |