Treatment of HIV AIDS with Dolutegravir-Based Regimen Antiretroviral Therapy

Treatment of HIV/AIDS with “Dolutegravir-Based Regimen” Antiretroviral Therapy

Name: Worapong Nasomsong

Address: 333 Moo1, Thasud, Muang, Chiang Rai 57100

Organization : School of Medicine, Mae Fah Luang University

Email : library@mfu.ac.th

Name: Chureeratana Bowonwatanuwong

keyword: Dolutegravir

ThaSH: Medicine

; Integrase strand transfer inhibitor

ThaSH: HIV (Viruses)

; HIV/AIDS

ThaSH: AIDS (Disease)

ThaSH: Antiviral agents

ThaSH: HIV infections -- Treatment

Abstract: Current guidelines recommend dolutegravir (DTG) as the first-line antiretroviral regimen in the treatment of HIV/AIDS. DTG is a second-generation integrase strand transfer inhibitor that has demonstrated high potency, high genetic barrier to resistance, tolerability, minimal drug-drug interactions, and convenience. DTG is also used in a 2-drug regimen among treatmentnaive individuals, as well as for switching regimens in virally suppressed HIV/AIDS patients with impaired renal function. However, DTG also has a few considerations. Firstly, DTG has revealed drug-drug interactions with antacids containing aluminum or magnesium, as well as with food or medications containing calcium, iron, or multivitamins, and metformin. Secondly, DTG can increase serum creatinine levels without impacting glomerular filtration rate by inhibiting tubular creatinine secretion. Finally, there was previously a recommendation against using DTG in pregnant women due to concerns about an increased risk of neural tube defects. However, it has been found that the incidence does not differ significantly from the general population. Therefore, almost all current guidelines permit the use of DTG in reproductive-age women and during pregnancy.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Modified: 2568-04-08

Issued: 2024-06-06

บทความ/Article

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BibliograpyCitation : GMS Medicine Journal. Vol.4, No.2 (May - August 2024) : p.63-70

GMS Medicine Journal Vol. 4 No. 2 May - August 2024 • 63-70

eng

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