Simulations of human modification glucose and insulin regulations system model

Name: Narisara Sensomied

ThaSH: Insulin -- Absorption and adsorption

ThaSH: Insulin -- Synthesis

ThaSH: Hypoglycemia

Abstract: In this work, a mathematical model of the control system of human circulating glucose concentration was examined. To this control system, a new variable was added to study the rate of reabsorption caused by glucose and insulin reactions in both normal and clinically treated subjects. This system of regulating blood sugar concentration allows the mathematical modeling of a system of three variable linear differential equations.This model was numerically analyzed using the Runge-Kutta method to determine the characteristics of glycemic homeostasis in normal and treated patients.Finally, we found this improved model, when the rate terms for glucose and insulin reaction were added.We found that the resulting curves showed the reaction rates of glucose uptake and insulin uptake in equilibrium that could be obtained and matched the actual reference levels for normal subjects (glucose level 70-110 mg/dl, insulin level 5-15 µU/mL)

King Mongkut's Institute of Technology Ladkrabang. Central Library

Address: BANGKOK

Email: Lifelong@kmitl.ac.th

Name: Kanchana Kumnungkit

Role: Thesis Advisor

Email : kanchana.ku@kmitl.ac.th

Email : kanchana.ku@kmitl.ac.th

Created: 2023

Modified: 2025-03-22

Issued: 2024-04-26

วิทยานิพนธ์/Thesis

application/pdf

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Applied Mathematics

Grantor: King Mongkut's Institute of Technology Ladkrabang

©copyrights King Mongkut's Institute of Technology Ladkrabang

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