Experimental study of radiolytic oxygen depletion from x-ray irradiation in water and liquid samples

Name: Pharewa Karoon

Organization : Nakhon Ratchasima. Suranaree University of Technology

Name: Chinorat Kobdaj

Organization : Nakhon Ratchasima. Suranaree University of Technology

Name: Chutima Talabnin

Organization : Nakhon Ratchasima. Suranaree University of Technology

Name: Fuss, Martina Christina

Organization : GSI Helmholtzzentrum fur Schwerionenforschung. Biophysics Department

keyword: X-ray irradiation

LCSH: Radiation chemistry

; FLASH irradiation

LCSH: Irradiation

; FLASH effect

Abstract: The mechanism underlying the reduction of toxicity in normal tissue caused by ultra-high dose rate irradiation (FLASH) is being investigated but still unknown. Oxygen depletion or the interaction of radiation-induced radicals with dissolved oxygen during irradiation may explain the FLASH effect. In this study, various liquid samples, including full oxygenated water, deoxygenated water, phosphate-buffered saline (PBS) and Ham’s F12 cell culture medium were irradiated with conventional dose rates to investigate experimental oxygen depletion in samples. The radiation-induced radical production and reactions were examined as a reference, before studying the oxygen depletion with FLASH irradiation. Samples were exposed to 50 Gy of X-ray radiation at a dose rate of 4.5–10.4 Gy/min. X-ray source dosimetry was performed using a Semiflex ionization chamber. A chemical optical sensor was used to measure the amount of oxygen, and the results were recorded online. The oxygen depletion was highest in the first irradiation step. The result showed that the depletion of oxygen in Ham’s F12 cell culture medium was highest with the value of 0.42 μM/Gy. Deoxygenated water and phosphate-buffered saline (PBS) had the lowest oxygen depletion with the value of 0.26 μM/Gy. For the irradiation in the second step, the results showed a similar trend of oxygen depletion that was lower than the first step and lowest depletion occurred in the third step of irradiation. We conclude that radical production and reactions, which compete with oxygen depletion, cause the declining behavior of oxygen depletion. Additionally, solutions containing organic compounds showed a greater depletion of oxygen.

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2023

Modified: 2024-04-26

Issued: 2024-04-26

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BibliograpyCitation : In Rangsit University. The 8th RSU International Research Conference on Sciences and Technology 2023 (RSUCON 2023) (pp.18-25). Pathum Thani : Rangsit University

eng

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