Intradermal injection autologous platelet rich plasma versus platelet rich fibrin in the treatment of melasma and striae distensae

Name: Patchanon Asawaworarit

keyword: Melasma

MeSH: Dermatology

Classification :.DDC: e-Theses

; Striae Distensae

MeSH: Patient satisfaction -- 137661

MeSH: Mole (Dermatology) -- Treatment -- 307328

MeSH: Blood platelets -- 31741

MeSH: Skin -- Diseases

LCSH: Dermatology

LCSH: Patient satisfaction -- 137661

LCSH: Mole (Dermatology) -- Treatment -- 307328

LCSH: Blood platelets -- 31741

LCSH: Skin -- Diseases

Abstract: This thesis investigates the comparative efficacy of Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF) in treating melasma and striae distensae, two common dermatological conditions with significant impacts on patients’ quality of life. Conducted at Mae Fah Luang University Hospital, Bangkok, this randomized, controlled, split-face, and split-abdomen trial involved 20 Thai female participants, aged 30-65 years, with Fitzpatrick skin types III to VI. Each participant received PRP on one side of the face and abdomen, and PRF on the other, thus allowing a direct comparison within the same individual. The study employed a robust methodology, utilizing a range of diagnostic tools to ensure a comprehensive evaluation of the treatment effects. The Mexameter® was used to measure melanin and erythema indices, essential in assessing melasma’s severity. The Antera 3D® system provided detailed analysis of skin texture, pigmentation, and redness, pertinent for evaluating the treatment’s impact on striae distensae. The VISIA® Complexion Analysis System was used for high-resolution, standardized facial imaging, enabling an objective evaluation of skin health and the treatment’s cosmetic outcomes. Clinical improvement was assessed using the Modified Melasma Area and Severity Index (mMASI) for melasma and the Patient and Observer Scar Assessment Scale (POSAS) for striae distensae. In this study, PRF treatment significantly reduced melasma severity over 12 weeks, more effectively than PRP, suggesting its potential superiority. For striae distensae, both PRP and PRF improved skin parameters, with PRF showing slightly better results in color, pigmentation, and texture reduction, confirmed by Mexameter® measurements. Patient satisfaction surveys indicated a preference for PRF, especially for melasma treatment. The study, conducted ethically, suggests PRP and PRF as viable, non-invasive options for these skin conditions, with PRF having a slight advantage. High patient satisfaction underscores the treatments' acceptability, important for treatment adherence. This research makes a significant contribution to the field of cosmetic dermatology, providing empirical evidence supporting the effectiveness of PRP and PRF treatments. It opens avenues for further research, particularly regarding the long-term effects of these treatments and their impact on patients’ psychological well-being. The study emphasizes the importance of patient-centered outcomes in dermatological research and the potential of PRP and PRF to meet patient needs in non-surgical skin rejuvenation.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Tanomkit Pawcsuntorn

Role: Advisor

Created: 2023

Modified: 2024-01-18

Issued: 2024-01-18

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: e-Theses

eng

DegreeName: Doctor of Philosophy

Level: Doctoral Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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