The efficacy of 5% safflower (Carthamus tinctorius L) seed extract cream on periorbital wrinkle reduction

Efficacy of 5% safflower (Carthamus tinctorius L) seed extract cream on periorbital wrinkle reduction

Name: Khin Ngu Wah Htoo

keyword: Carthamus tinctorius L

MeSH: Skin -- Wrinkles

Classification :.DDC: e-Theses

; Safflower Seed

MeSH: Safflower -- Extracts -- 306458

MeSH: Eye -- Wrinkles -- 306459

LCSH: Skin -- Wrinkles

LCSH: Safflower -- Extracts -- 306458

LCSH: Eye -- Wrinkles -- 306459

Abstract: Background: Wrinkles around the eyes result from both intrinsic and extrinsic factors. To inhibit and prevent the formation of wrinkles, antioxidants play a crucial role by inhibiting MMPs and decreasing reactive oxygen species. Safflower (Carthamus tinctorius L) seed extract is well-known for its not only containing large amount of linoleic acid but also consisting α tocopherol, flavonoids, polyphenols that take part in major role in maintaining skin barrier function and also gives antioxidant property. Objective: To study effectiveness and satisfaction of safflower (Carthamus tinctorius L) seed extract cream to reduce periorbital wrinkles. Method: 12 healthy volunteers, both male and female of age between 32 and 60 years old were recruited to participate in double-blind, split face, placebo base cream-controlled trial for 12 weeks. 5% (Carthamus tinctorius L) safflower seed extract cream and placebo base cream were instructed to apply in the morning and at night around the eye areas on each side for 12 weeks. Skin elasticity, skin hydration, trans-epidermal water loss and wrinkle assessment were done at baseline, 4th, 8th and 12th week respectively. Result: After comparing with placebo base cream, 5% safflower seed extract cream have better statistically significant results in skin elasticity, better hydration. And the volunteers also gave satisfactory result in safflower seed extract cream treated side than placebo base cream treated side. Conclusions: This study pointed that (Carthamus tinctorius L) safflower seed extract cream reduced periorbital wrinkles more than placebo-based cream without any side effects and complication. Therefore, we can conclude that applying 5% safflower (Carthamus tinctorius L) seed extract cream could be safe and effective in treating periorbital wrinkles.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Tanomkit Pawcsuntorn M. D.

Role: Advisor

Created: 2023

Modified: 2023-10-04

Issued: 2023-10-04

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: e-Theses

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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