In vitro evaluation of biological activity and chemical constituents of croton fluviatilis, croton acutifolius and croton thorelii

Name: Charina Worarat

keyword: croton fluviatilis

ThaSH: Biochemistry

Classification :.DDC: 572.45

; croton acutifolius

ThaSH: Biosynthesis

; croton thorelii

Abstract: The biological activity of the ethyl acetate extract of C. acutifolius and the hexane extract of C. fluviatilis were exhibited moderate anti-HIV1-RT activity toward the HIV1-RT at % inhibition of 64.89 and 56.25, respectively, while the ethyl acetate extracts of C. thorelii and C. fluviatilis showed good inhibitory values of HIV1-RT at 69.77, and 79.07 %, respectively. In addition, the ethyl acetate extract of C. fluviatilis showed low anti-bacterial activity against E. aerogenes, E. coli 0157: H7, and P. mirabilis, together with the ethyl acetate extract of C. acutifolius displayed low antibacterial activity against E. aerogenes, while all the crude extracts of C. theolii were inactive. Cytotoxic properties of three Croton plants were specific to KKU-M213, A-549, and MMNK-1. Especially, the ethyl acetate extract of C. acutifolius exhibited strong cytotoxic activities against MDA-MB-231, A-549, and MMNK-1. Furthermore, the ethyl acetate extract of C. thorelii showed high cytotoxic activities against KKU- M213, and MDA-MB-231. Phytochemical investigation of three Croton species was founded that the chemical compounds of hexane extract from the stems of C. fluviatilis were afforded β-amyrin (1) and a mixture of stigmasterol, and β-sitosterol (4). The hexane extract from twigs and leaves of C. acutifolius provided retusin (2) and (4). 5-hydroxy-7,4ʹ-dimethoxyflavone (3) had been isolated from the hexane extract from stems of C. thorelii. The structures of these compounds were elucidated by using UV, IR, NMR, MS spectral data, and comparison of these data with those reported in the literature.

Lampang Rahjabhat University

Address: Lampang

Email: lprulibrary1@gmail.com

Name: WILART POMPIMON, Ph.D.

Role: THESIS ADVISOR

Name: PHANSUANG UDOMPUTTIMEKAKUL, Ph.D.

Role: THESIS ADVISOR

Created: 2021

Modified: 2023-09-14

Issued: 2023-09-14

วิทยานิพนธ์/Thesis

application/pdf

RES 572.45 C473I

eng

DegreeName: Master of Science Program

Level: Master's Degree

Descipline: Applied Chemistry

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