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Pichamon Kiatwuthinon. Synthesis and anti-cancer activities of the stereoisomers of cordyceamide A in a skin carcinoma cell line. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2023.
Synthesis and anti-cancer activities of the stereoisomers of cordyceamide A in a skin carcinoma cell line
Name: Suppakorn Netmanee
Organization :
Kasetsart University. Faculty of Science
Name: Satapanawat Sittihan
Organization :
Center of Excellence on Environmental Health and Toxicology (EHT). Chulabhorn Graduate Institute
Name: Teeraphan Laomettachit
Organization :
King Mongkut's University of Technology Thonburi. School of Bioresources and Technology
Name: Passorn Wonnapinijt
Organization :
Kasetsart University. Faculty of Science
Organization :
Kasetsart University. Faculty of Science
Name: Pichamon Kiatwuthinon
Organization :
Kasetsart University. Faculty of Science
Email :
fscipmk@ku.ac.th
LCSH:
Stereoisomers
Abstract:
Cordyceps (Ophiocordyceps sinensis) is a fungus reported with broad biological activities including
cancer growth inhibition. Its extract contains several natural products such as cordycepin, cordyceamide A,
and cordycepic acid. As a result, the identification and understanding of cellular mechanisms of inhibition are
essential to further develop cordyceps as anti-cancer agents. This study aims to synthesize diastereomers of
cordyceamide A and examine their anticancer activities, including proliferation, apoptosis, and migration on
A431 skin cancer cells, and anti-inflammatory activity on macrophage cells. Firstly, two diastereomers of
cordyceamide A (DD and LD) were synthesized via an amide coupling reaction between N-benzoyltyrosine
and O-acetyl-phenylalaninol in the presence of dicyclohexy1 carbodiimide (DCC) and a catalytic amount of
hydroxybenzotriazole (HOBt) in 70-75% yields. The mixture of DD and LD isomers showed a suppression
of A431 growth with IC50 values of 16.12 uM at 72 h. Furthermore, the diastereomers of cordyceamide A
promoted DNA fragmentation, indicating apoptotic-mediated cell death. Additionally, the migration of A431
cells was drastically suppressed in the presence of the diastereomer mixture of cordyceamide A. Also, the role
of the DD and LD mixture in inhibiting inflammation, considered as a cause of cancers, was investigated by
determining nitric oxide production. The results revealed a promising but non-substantial reduction in the
nitric oxide production in macrophage cells. Collectively, the chemically synthesized diastereoisomers of
cordyceamide A possess anti-cancer activity over a skin cancer cell line and can potentially be developed for
skin cancer treatment
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2023
Modified:
2023-06-26
Issued:
2023-06-26
บทความ/Article
application/pdf
BibliograpyCitation :
In Mae Fah Luang University. School of Science. The Pure and Applied Chemistry International Conference 2023 (PACCON 2023) (pp.736-740). Chiang Rai : Mae Fah Luang University
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.032483 วินาที
Suppakorn Netmanee
| Title | Contributor | Type |
|---|---|---|
| Synthesis and anti-cancer activities of the stereoisomers of cordyceamide A in a skin carcinoma cell line
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Suppakorn Netmanee;Satapanawat Sittihan;Teeraphan Laomettachit;Passorn Wonnapinijt;Napachanok Mongkoldhumrongkul;Pichamon Kiatwuthinon | บทความ/Article |
Satapanawat Sittihan
| Title | Contributor | Type |
|---|---|---|
| Synthesis and anti-cancer activities of the stereoisomers of cordyceamide A in a skin carcinoma cell line
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Suppakorn Netmanee;Satapanawat Sittihan;Teeraphan Laomettachit;Passorn Wonnapinijt;Napachanok Mongkoldhumrongkul;Pichamon Kiatwuthinon | บทความ/Article |
Teeraphan Laomettachit
| Title | Contributor | Type |
|---|---|---|
| Synthesis and anti-cancer activities of the stereoisomers of cordyceamide A in a skin carcinoma cell line
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Suppakorn Netmanee;Satapanawat Sittihan;Teeraphan Laomettachit;Passorn Wonnapinijt;Napachanok Mongkoldhumrongkul;Pichamon Kiatwuthinon | บทความ/Article |
Passorn Wonnapinijt
| Title | Contributor | Type |
|---|---|---|
| Synthesis and anti-cancer activities of the stereoisomers of cordyceamide A in a skin carcinoma cell line
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Suppakorn Netmanee;Satapanawat Sittihan;Teeraphan Laomettachit;Passorn Wonnapinijt;Napachanok Mongkoldhumrongkul;Pichamon Kiatwuthinon | บทความ/Article |
Napachanok Mongkoldhumrongkul
| Title | Contributor | Type |
|---|---|---|
| Synthesis and anti-cancer activities of the stereoisomers of cordyceamide A in a skin carcinoma cell line
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Suppakorn Netmanee;Satapanawat Sittihan;Teeraphan Laomettachit;Passorn Wonnapinijt;Napachanok Mongkoldhumrongkul;Pichamon Kiatwuthinon | บทความ/Article | |
| Advantages of electro-deposited gold on carbon electrodes for NT-proBNP immunosensor for development of heart failure test kit
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Pongsakorn Aiemderm.;Kanchana Monkhang.;Sureeporn Wongjard.;Kiattawee Choowongkomon.;Napachanok Mongkoldhumrongkul Swainson.;Chaiya Prasittichai.;Charoenkwan Kraiya. | บทความ/Article |
Pichamon Kiatwuthinon
| Title | Contributor | Type |
|---|---|---|
| Synthesis and anti-cancer activities of the stereoisomers of cordyceamide A in a skin carcinoma cell line
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Suppakorn Netmanee;Satapanawat Sittihan;Teeraphan Laomettachit;Passorn Wonnapinijt;Napachanok Mongkoldhumrongkul;Pichamon Kiatwuthinon | บทความ/Article |