Potential of waste Macadamia (Macadamia integrifolia) pericarp as cosmeceutical active ingredients

Name: Suvimol Somwongin

Organization : Chiang Mai University. Faculty of Pharmacy

Name: Sasithorn Sirilun

Organization : Chiang Mai University. Faculty of Pharmacy

Name: Panuwan Chantawannakul

Organization : Chiang Mai University. Faculty of Science

Name: Songyot Anuchapreeda

Organization : Chiang Mai University. Faculty of Associated Medical Sciences

Name: Wantida Chaiyana

Organization : Chiang Mai University. Faculty of Pharmacy

keyword: Cosmeceutical

ThaSH: Cosmetics

ThaSH: Macadamia integrifolia

ThaSH: Antioxidants

Abstract: Macadamia (Macadamia integrifolia) pericarps are waste product from macadamia nut production. This study aimed to investigate the potential of M. integrifolia pericarp extract for using as cosmeceutical active ingredients. The pericarp of M. integrifolia was extracted by sequential maceration using various solvents, started from n-hexane, followed by ethyl acetate and 95 percent v/v ethanol, respectively. The extracts were then investigated for the antioxidant activities by 2,2' -diphenyl-1- picrylhydrazyl (DPPH), 2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid), and ferric reducing/antioxidant power assay. The whitening effects of the extracts were determined through tyrosinase inhibition when the substrates were L-tyrosine and LDOPA. Besides, anti-skin ageing effects were determined through collagenase and elastase inhibitions. The results remarked that the ethanolic extract yielded the highest extract content, contained the highest phenolics content, and possessed the highest cosmeceutical activities, including antioxidant, anti-tyrosinase, and anti-skin ageing effects (p < 0.05). This extract possessed the highest DPPH inhibition (57.0 + 2.2 percent), equivalent concentration (EC1) (51.9 + 0.7 mM FeSO4/g extract), Trolox equivalent antioxidant capacity (118.8 + 0.9 mM Trolox/g extract), anti-tyrosinase activity on the conversion of L-tyrosine (26.4 + 3.2 percent) and L-DOPA (27.1 + 2.4 percent), anti-collagenase (65.4 + 2.4 percent), and anti-elastase (68.3 + 2.3 percent). Therefore, the ethanolic extract of M. integrifolia pericarp was a promising natural extract for using as a cosmeceutical active ingredient and suggested for further cosmetic and cosmeceutical product development.

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2021

Modified: 2023-05-30

Issued: 2023-05-30

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BibliograpyCitation : In Thai Society for Biotechnology. Thai Society for Biotechnology and International Conference Online (TSB Online 2021) (pp.328-336). Bangkok : Thai Society for Biotechnology

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