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Chutinan Chueachavalit. Comparison of Malassezia spp. colonization between human skin exposed to high and low ambient air pollution. Master's Degree(Dermatology). Thammasat University. Thammasat University Library. : Thammasat University, 2021.
Comparison of Malassezia spp. colonization between human skin exposed to high and low ambient air pollution
Name: Chutinan Chueachavalit
keyword:
Malassezia spp.
;
Fungus
Abstract:
Background: The skin microbiota is essential for human health ; altered skin microbiome colonization and homeostasis may be associated with several inflammatory skin conditions and other inflammatory diseases. The effects of particulate matter of diameter less than 2.5 micrometers (PM2.5) on the skin and the skin microbiome are poorly understood. Malassezia spp. are commensal fungi commonly found on the human skin, and they also play a pathogenic role in various skin diseases. It is hypothesized that the exposure of human skin to air pollution with a high concentration of PM2.5 might be associated with Malassezia spp. colonization. The aim of this study was to compare Malassezia spp. colonization on healthy human skin between people living in two major cities in Thailand with different air qualities: one city with highly polluted ambient air and the other with less polluted air. Methods: Skin microbiome samples from 66 participants were collected using swabbing and scraping techniques. The skin fungal composition was analyzed using high-throughput sequencing based on internal transcribed spacer 2 (ITS2) rDNA. Results: A significant difference was found in alpha and beta diversities and the relative abundance of fungal profiles between the groups. The relative abundance of Malassezia spp. was found to be significantly higher in the highly polluted area than in the less polluted area.Conclusion: This study demonstrates that ambient air polluted with high concentrations of PM2.5 may alter Malassezia spp. colonization on healthy human skin, which could lead to dysbiosis of the cutaneous ecosystem and eventually result in some skin disorders
Thammasat University. Thammasat University Library
Address:
BANGKOK
Email:
preserv@tu.ac.th
Name: Jitlada Meephansan
Role:
advisor
Created:
2021
Modified:
2023-04-10
Issued:
2023-04-10
วิทยานิพนธ์/Thesis
application/pdf
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Dermatology
Grantor: Thammasat University
©copyrights Thammasat University
RightsAccess:
ใช้เวลา
0.026785 วินาที
Chutinan Chueachavalit
| Title | Contributor | Type |
|---|---|---|
| Comparison of Malassezia spp. colonization between human skin exposed to high and low ambient air pollution
มหาวิทยาลัยธรรมศาสตร์ Chutinan Chueachavalit | Jitlada Meephansan | วิทยานิพนธ์/Thesis |
Jitlada Meephansan