The characteristics of thermal respond during microwave ablation process using slot antenna in liver tissue : bioheat model embedded with large blood vessels&porous liver model

คุณลักษณะของการตอบสนองเชิงความร้อนในกระบวนการรักษาด้วยไมโครเวฟโดยใช้ท่อนำคลื่นในเนื้อเยื่อตับ : โมเดลไบโอฮีตที่มีเส้นเลือดใหญ่ฝังอยู่&โมเดลตับที่พิจารณาเป็นวัสดุพรุน

Name: Wutipong Preechapolkul

keyword: Microwave ablation

; Heat transfer

; Bioheat

; Porous media

; 3D Numerical simulation

; FEM

; Comparative thermal

; Local thermal equilibrium (LTE)

; Liver cancer

; Thermal ablation

Abstract: Microwave ablation (MWA) is a minimally invasive cancer treatment technique that induces thermal injury into the tumor by using microwave energy. This treatment applies microwave energy to the tumor by using the microwave antenna. The microwave energy is absorbed and converted to heat generation in the unwanted tissue. The goal of this treatment is to generate heat damaged by microwave energy in the tumor and unwanted heat to the surrounding tissue. The advantages of this treatment are rapid, effective, and non-toxic side effects. However, microwave ablation has dangerous when used incorrect conditions during treatment. Therefore, the studies of correct conditions are necessary. The modeling for heat transport in the biological tissue was applied in the therapeutics application for preventing injury and analyzing the effectiveness of the treatment process. However, the specific treatment area and comparative studies of the heating models were not investigated systematically. This dissertation presented the numerical analysis of specific absorption rate and heat transfer in liver cancer during MWA treatment by using a coaxial slot antenna. The mathematical model is considered coupled with the electromagnetic wave propagation and heat transfer in the biological tissue. The coupled nonlinear set of these equations is solved using the finite element method (FEM). The influence of the large vessel locality was systematically investigated on the specific absorption rate and heat transfer in the 3D liver cancer domain. The results show the volumetric of damaged tissue in the model with a vertical blood vessel is lower than the model with a horizontal vessel. Furthermore, this result presented the asymmetrical temperature distribution, which indicated the necessity for the 3D assumption. Moreover, this dissertation presented the comparative performance of the thermal model during the MWA process. The comparative thermal models implemented in this work were the bioheat model, the porous media model with constant velocity, and the Darcy-Brinkman porous model in the liver cancer model during the MWA process. The results show the Darcy-Brinkman porous model has a flexible use than the porous model with constant velocity and the bioheat model. The Darcy-Brinkman porous model was effective in various situations of predictions as compared to other models, since the role of conduction and the role of convection were combined. The value of the dissertation provides an indication of limitations that must be considered in administering microwave ablation therapy

Thammasat University. Thammasat University Library

Address: BANGKOK

Email: preserv@tu.ac.th

Name: Phadungsak Ratanadecho

Role: advisor

Created: 2020

Modified: 2023-02-24

Issued: 2023-02-24

วิทยานิพนธ์/Thesis

application/pdf

DOI: 10.14457/TU.the.2020.1177

eng

DegreeName: Doctor of Philosophy

Level: Doctoral Degree

Descipline: Engineering

Grantor: Thammasat University

©copyrights Thammasat University

ลำดับที่.	ชื่อแฟ้มข้อมูล	ขนาดแฟ้มข้อมูล	จำนวนเข้าถึง	วัน-เวลาเข้าถึงล่าสุด
1	10699wutipong.pdf	4.42 MB	1	2023-07-08 05:49:12

ใช้เวลา

0.026572 วินาที