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Voravee P. Hoven. PEG-containing amphiphilic copolymers: preparation by postpolymerization modification and micelles formation. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2016.
PEG-containing amphiphilic copolymers: preparation by postpolymerization modification and micelles formation
Name: Susita Noree
Organization :
Chulalongkorn University. Faculty of Science
Name: Varawut Tangpasuthadol
Organization :
Chulalongkorn University. Faculty of Science
Name: Voravee P. Hoven
Organization :
Chulalongkorn University. Faculty of Science
Email :
vipavee.p@chula.ac.th
keyword:
Copolymers
LCSH:
Polyethylene glycol
LCSH:
Polymerization
Abstract:
Amphiphilic random copolymer designed to be used as drug carrier were prepared via
post-polymerization modification of poly(pentafluorophenyl methacrylate) (PPFPMA) with
poly(ethylene glycol) methyl ether amine (PEG-NH2). PPFPMA was first synthesized using
reversible addition−fragmentation chain transfer polymerization (RAFT). The
pentafluorophenyl (PFP) active ester groups of the PPFPMA reacted with the PEG-NH2 and
yielded PEG-containing amphiphilic copolymer (P(PFPMA-co-PEGMAM). The composition
of PEG in the copolymer was varied from 27 to 54 and 74%. The size of micelles selfassembled
from the copolymer in water was found to increase with the increasing PEG
composition in a range of 80-600 nm. It is our on-going effort to introduce cleavable dithiol
crosslinking to the micelles via tandem post-polymerization modification of the remaining
PFP active ester groups in the copolymer with cystamine. The ability to encapsulate a
hydrophobic dye by the micelles is also explored
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2016
Modified:
2023-01-09
Issued:
2023-01-09
บทความ/Article
application/pdf
BibliograpyCitation :
In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn and Chulalongkorn University Faculty of science. Pure and Applied Chemistry International Conference (PACCON 2016) (pp.1345-1350). Bangkok : Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn
eng
©copyrights King Mongkut's University of Technology North Bangkok
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Susita Noree
| Title | Contributor | Type |
|---|---|---|
| PEG-containing amphiphilic copolymers: preparation by postpolymerization modification and micelles formation
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Susita Noree;Varawut Tangpasuthadol;Voravee P. Hoven | บทความ/Article |
Varawut Tangpasuthadol
| Title | Contributor | Type |
|---|---|---|
| PEG-containing amphiphilic copolymers: preparation by postpolymerization modification and micelles formation
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Susita Noree;Varawut Tangpasuthadol;Voravee P. Hoven | บทความ/Article |
Voravee P. Hoven
| Title | Contributor | Type |
|---|---|---|
| Liposomes conjugated with poly(2-ethyl-2-oxazoline) as potential carriers for nucleic acid delivery
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Pongsakorn Yuntasini;Voravee P. Hoven | บทความ/Article | |
| PEG-containing amphiphilic copolymers: preparation by postpolymerization modification and micelles formation
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Susita Noree;Varawut Tangpasuthadol;Voravee P. Hoven | บทความ/Article |