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Trirath Sukthawee. Bioassay-guided isolation and identification of bioactive compounds from Leonurus japonicus houtt extract. Master's Degree(Applied Chemistry). Mae Fah Luang University. Learning Resources and Educational Media Center. : Mae Fah Luang University, 2022.
Bioassay-guided isolation and identification of bioactive compounds from Leonurus japonicus houtt extract
Name: Trirath Sukthawee
keyword:
Leonurus japonicus
MeSH:
Bioactive compounds
-- 295047
Classification :.DDC: e-Theses
MeSH:
Glucosidase inhibitors
-- 295048
MeSH:
Antifungal agents
-- 295049
LCSH:
Bioactive compounds
-- 295047
LCSH:
Glucosidase inhibitors
-- 295048
LCSH:
Antifungal agents
-- 295049
Abstract:
Leonurus japonicus (L. japonicus) is widely used in folk medicine to treat diabetes, menstrual irregularities, and bronchitis. This study evaluated the α-glucosidase inhibitory and anti-inflammatory activity of the crude extract, semipurified fractions, and isolated compounds from the areal of L. japonicus, through bioassay-guided testing. The crude extract was obtained with an ethanolic extract and then partitioned with ethyl acetate. Bioassay-guided fractionation of an EtOAc-soluble extract of arial of L. japonicas led to the isolation of six known compounds (T-1 to T-6). Their structures were elucidated based on data analysis, including 1H NMR data, LC-QTOF-MS, ECD, UV, and FT-IR. Compounds T-1 to T-6 exhibited α-glucosidase inhibitory and anti-inflammatory activity in range IC50 values at 143.9 - 598.4 μM and 66.9 - 285.8 μM, respectively, when compared with the positive control.
Mae Fah Luang University. Learning Resources and Educational Media Center
Address:
CHIANG RAI
Email:
library@mfu.ac.th
Name: Tharakorn Maneerat
Role:
Advisor
Created:
2022
Modified:
2022-12-28
Issued:
2022-12-28
วิทยานิพนธ์/Thesis
application/pdf
CallNumber:
e-Theses
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Applied Chemistry
Grantor: Mae Fah Luang University
©copyrights Mae Fah Luang University
RightsAccess:
ใช้เวลา
0.029829 วินาที
Trirath Sukthawee
| Title | Contributor | Type |
|---|---|---|
| Bioassay-guided isolation and identification of bioactive compounds from Leonurus japonicus houtt extract
มหาวิทยาลัยแม่ฟ้าหลวง Trirath Sukthawee | Tharakorn Maneerat | วิทยานิพนธ์/Thesis |
Tharakorn Maneerat
| Title | Creator | Type and Date Create |
|---|---|---|
| Chemical constituents and biological activities from desmos chinensis lour, maclura cochinchinensis (lour) corner, maclura fruticosa (roxb) corner, and monoon membranifolium (jsinclair) bxue & rmksaunders
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| Bioassay-guided isolation and identification of bioactive compounds from Leonurus japonicus houtt extract
มหาวิทยาลัยแม่ฟ้าหลวง Tharakorn Maneerat | Trirath Sukthawee | วิทยานิพนธ์/Thesis |
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มหาวิทยาลัยแม่ฟ้าหลวง Tharakorn Maneerat | Chalinee Janta | วิทยานิพนธ์/Thesis |