Analysis of cannabinoids in oil using Raman spectroscopy and comparison with HPLC

Name: Jittipon Wuttirattanarak

Organization : Kasetsart University. Faculty of Science

Name: Chalisa Moolek

Organization : National Science and Technology Development Agency (NSTDA). National Electronics and Computer Technology Center (NECTEC)

Name: Orapin Chienthavorn

Organization : Kasetsart University. Faculty of Science

Name: Thitaphat Ngernsutivorakul

Organization : National Science and Technology Development Agency (NSTDA). National Electronics and Computer Technology Center (NECTEC)

Email : thitaphat.ngernsutivorakul@nectec.or.th, fsciopc@ku.ac.th

LCSH: Cannabinoids -- Analysis

LCSH: Raman spectroscopy

Abstract: Cannabinoids, namely delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), are the main components of cannabis oil. Monitoring of these compounds in oil products is necessary to ensure their quality and safe uses. We have developed a time and cost-effective method for cannabinoid analysis in oil samples by using Raman spectroscopy. Coconut oil was selected as a representative matrix. Raman spectral profiles of the analytes and matrix were initially collected as references. A quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction was also modified for preparing a small drop of samples (50 μL). For Raman measurements, 2.5 μL of the extracts were drop-dried on aluminum foil and Raman spectra were collected in the range of 620-1720 cm-1 using a laser wavelength of 785 nm. Analysis of the cannabinoids in the oil samples was successfully demonstrated. At the cut-off analyte concentration of 0.2% w/v, extraction recoveries were > 70% and %RSDs were < 20%. Calibration curves were obtained with good linearity (R2 > 0.95). The overall method was fast, inexpensive, and reliable. Furthermore, a HPLC method was developed in parallel in for comparison. The Raman results agreed reasonably well with the HPLC results. This work holds potential for several cannabis testing applications

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2022

Modified: 2022-11-08

Issued: 2022-11-08

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BibliograpyCitation : In King Mongkut's Institute of Technology Ladkrabang. Pure and Applied Chemistry International Conference (PACCON 2022) (pp.56-60). Bangkok : King Mongkut's Institute of Technology Ladkrabang

eng

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