Impact of nonselective muscarinic cholinergic antagonist (atropine) on goat semen quality and seminal fluid volume

ผลของยากลุ่มปิดกั้นการจับตัวรับชนิดมัสคารินิก โคลิเนอจิก แบบไม่เลือก (อะโทรปีน) ต่อคุณภาพน้้าเชื้อและปริมาณน้้าเลี้ยงอสุจิแพะ

Name: Sakdichod Kimsakulvech

Organization : Mahidol University.Faculty of Veterinary Science.Department of Preclinic and Applied Animal Sciences

Name: Tuempong Wongtawan

Organization : Walailak University.Akkhararatchakumari Veterinary College

Name: Sookruetai Boonmasawai

Organization : Mahidol University.Faculty of Veterinary Science.Department of Preclinic and Applied Animal Sciences

Name: Arpron Leesombun

Organization : Mahidol University.Faculty of Veterinary Science.Department of Preclinic and Applied Animal Sciences

Name: Chowalit Nakthong

Organization : Mahidol University.Faculty of Veterinary Science.Department of Clinical science and Public health

Name: Yupaporn Lanamtiang

Organization : Mahidol University.Faculty of Veterinary Science.Veterinary Medical Center for Livestock and Wildlife Animal Hospital

Name: Waraluk Oupala

Organization : Mahidol University.Faculty of Veterinary Science.Veterinary Medical Center for Livestock and Wildlife Animal Hospital

keyword: Atropine

; Goat

; Parasympathetic inhibition

; Semen quality

; Seminal fluid

Abstract: The parasympathetic nervous system plays an important role in controlling the semen quality via manipulation of accessory glands in many species. Seminal fluid has a negative impact on semen cryopreservation in goats. We hypothesized that reducing the secretion of seminal fluid during semen collection may help to improve the quality of semen cryopreservation. In this study, we used atropine to inhibit the parasympathetic pathway. Six different concentrations(0.02, 0.04, 0.08, 0.1, 0.15 and 0.2 mg/kg) of atropinewere tested in twelve male goats. The final concentration (0.2 mg/kg) was tested in two consecutive semen collections. Physiological changes, including heart rate and pupil response, were evaluated before and after the atropine injection. The results revealed that atropine did not affect most of the reproductive system, including copulation, ejaculation,semen quality and seminal fluid volume, protein concentration and protein profile. However, some dosages of atropine affected other body systems, such as increased heart rate at a dose of more than 0.1 mg/kg and pupil dilation at a dose greater than 0.04 mg/kg. In conclusion, we proposed that parasympathetic inhibition by atropine did not impact the goat’s male reproductive system and suggested that the parasympathetic system may not be important for regulating the male reproductive system in goats.

Mahanakorn University of Technology. Library

Address: BANGKOK

Email: mutelibrary@gmail.com

Created: 2022

Modified: 2022-10-20

Issued: 2022-10-20

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BibliograpyCitation : สัตวแพทย์มหานครสาร. ปีที่ 17, ฉบับที่ 1 (ม.ค.-มิ.ย. 2565), หน้า 49-59

eng

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