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Somrat Charuluxananan. Melatonin Decreased Postoperative Pain after Abdominal Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial. (). Mae Fah Luang University. Learning Resources and Educational Media Center. : , .
Melatonin Decreased Postoperative Pain after Abdominal Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial
Name: Prok Laosuwan
Address:
333 Moo1, Thasud, Muang, Chiang Rai 57100
Organization :
School of Medicine, Mae Fah Luang University
Email :
ask.library@mfu.ac.th
Name: Kamonwan Dechaworawut
Name: Oraluxna Rodanant
Name: Somrat Charuluxananan
keyword:
Melatonin
ThaSH:
Melatonin
ThaSH:
Hysterectomy
ThaSH:
Postoperative pain
Abstract:
Background: Incidence of anxiety and pain in patients undergoing hysterectomy is significant and primarily due to postoperative pain. Most patients usually receive opioids for pain control. Melatonin is a natural hormone produced by the body. Synthetic melatonin is available over the counter for the management of insomnia and jetlag. Clinically, melatonin can also be used to reduce pain and analgesic requirement in patients undergoing surgery. The analgesic benefit of melatonin as primary or adjuvant agents has been reported in various studies.
Objective: We aimed to study whether melatonin could improve pain and other postoperative conditions after hysterectomy.
Methods: A randomized, double-blinded, placebo-controlled trial study was carried out on 54 women undergoing hysterectomy, with or without oophorectomy under spinal anesthesia. Patients were allocated randomly to receive either 4 mg prolonged-release melatonin at night and in the morning before surgery or 2 doses of placebo. Morphine consumption within 24 hours, visual analog scale (VAS) pain score, quality of sleep, anxiety level score, fatigue, general well-being and satisfaction score were measured.
Results: Morphine consumption in melatonin group was significantly low compared to placebo (33.04 ± 10.42 and 42.63 ± 8.21 mg, (p < 0.001). Also, postoperative VAS pain scale was lower in the melatonin group at recovery room arrival (23.41 vs 8.07, p = 0.01). Postoperative fatigue, general well-being and satisfaction scores in the melatonin group were better than the placebo group.
Conclusion: Prolonged-release formulation of melatonin decreased pain intensity in post anesthetic care room and reduced morphine consumption within 24 hours after surgery. Melatonin may be an additional choice of multimodal analgesia for hysterectomy.
Mae Fah Luang University. Learning Resources and Educational Media Center
Address:
CHIANG RAI
Email:
library@mfu.ac.th
Modified:
2022-09-05
Issued:
2022-09-03
บทความ/Article
application/pdf
GMS Medicine Journal Vol. 2 No. 1 January-April 2022 1-13
eng
©copyrights Mae Fah Luang University
RightsAccess:
ใช้เวลา
0.040496 วินาที
Prok Laosuwan
| Title | Contributor | Type |
|---|---|---|
| Melatonin Decreased Postoperative Pain after Abdominal Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial
มหาวิทยาลัยแม่ฟ้าหลวง Prok Laosuwan;Kamonwan Dechaworawut;Oraluxna Rodanant;Dhammika Leshan Wannigama;Somrat Charuluxananan | บทความ/Article |
Kamonwan Dechaworawut
| Title | Contributor | Type |
|---|---|---|
| Melatonin Decreased Postoperative Pain after Abdominal Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial
มหาวิทยาลัยแม่ฟ้าหลวง Prok Laosuwan;Kamonwan Dechaworawut;Oraluxna Rodanant;Dhammika Leshan Wannigama;Somrat Charuluxananan | บทความ/Article |
Oraluxna Rodanant
| Title | Contributor | Type |
|---|---|---|
| Melatonin Decreased Postoperative Pain after Abdominal Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial
มหาวิทยาลัยแม่ฟ้าหลวง Prok Laosuwan;Kamonwan Dechaworawut;Oraluxna Rodanant;Dhammika Leshan Wannigama;Somrat Charuluxananan | บทความ/Article |
Dhammika Leshan Wannigama
| Title | Contributor | Type |
|---|---|---|
| Melatonin Decreased Postoperative Pain after Abdominal Hysterectomy: A Randomized, Double-blind, Placebo-controlled Trial
มหาวิทยาลัยแม่ฟ้าหลวง Prok Laosuwan;Kamonwan Dechaworawut;Oraluxna Rodanant;Dhammika Leshan Wannigama;Somrat Charuluxananan | บทความ/Article | |
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Somrat Charuluxananan