Antioxidant capacity and inhibitory effect on dna damage of some nepenthes species

Name: Phanutchanat Nontesa

LCSH: Burapha University.Faculty of Science

Classification :.DDC: 541.224

LCSH: Free radicals (Chemistry)

Abstract: An imbalance between free radicals and antioxidants often causes injury to various biomolecules. Especially when damage to DNA results in diseases such as Parkinson's, Alzheimer's, and cancers. Nepenthes is a carnivorous plant in Southeast Asia used as a folklore medicine for various diseases because it is rich in phytochemicals. However, the bioactivity of Nepenthes notably different species in Thailand still has data very rare. Therefore, the objective of this study was to assess the free radical scavenging activity and inhibitory effect against DNA damage of some Nepenthes species, for example, parental species (N. mirabilis; M and N. ampullaria spot; AP), natural hybrid species (N. mirabilis var. globosa; MG) and man-made hybrid species including N. mirabilis var. globosa x N. rafflesiana; MGR, N. mirabilis var. globosa x N. ampullaria spot; MGAP, N. mirabilis var. globosa x N. ampullaria red; MGAR and N. mirabilis var. globosa x N. ampullaria black; MGAB. The results showed that ethanol extracts of all Nepenthes were abundant in phenolic compounds and flavonoids. It also could scavenge free radicals—especially MGAB extract, which was remarkable in eliminating DPPH and peroxyl radicals. In addition, the MGAB extract was also sub-extracted with hexane, chloroform, ethyl acetate, and water. Furthermore, it was indicated that most of the MGAB sub-extracts were rich in rutin and quercetin, which could also scavenge free radicals. Moreover, for the protective activity on DNA damage, it revealed that the ethanol extract and the sub-extract of each Nepenthes species could inhibit the conversion from a supercoiled form into an open circular form. From the results, local Thai Nepenthes may be possible to use for health or pharmaceutical products.

Burapha University. Library

Address: CHONBURI

Email: buulibrary@buu.ac.th

Name: Chatchawin Petchlert

Role: Principal advisor

Created: 2564

Modified: 2022-05-24

Issued: 2022-05-24

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Th 541.224 Ph535A

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Biochemistry

Grantor: Burapha University

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