A split-face double-blind randomized placebo-controlled trial of the effectiveness of 5% kaempferia parviflora extract for treatment of melasma

Split-face double-blind randomized placebo-controlled trial of the effectiveness of 5% kaempferia parviflora extract for treatment of melasma

Name: Okkar Kyaw Khant

keyword: Kaempferia parviflora

MeSH: Dermatology -- treatment -- 262785

Classification :.DDC: WR140

; Krachaidam

MeSH: Skin Diseses -- therapy -- 275434

MeSH: Dermotology -- methods -- 275435

MeSH: Melasma -- treatment -- 275436

LCSH: Dermatology -- treatment -- 262785

LCSH: Skin Diseses -- therapy -- 275434

LCSH: Dermotology -- methods -- 275435

LCSH: Melasma -- treatment -- 275436

Abstract: Background: Melasma is a common hyperpigmentary disorder that can cause significant psychosocial distress and quality of life impairments. Krachaidam (Kaempferia parviflora) extract is well known for its several methoxy flavones that has the anti-tyrosine activity and can inhibit the effect in melanin synthesis which can relief of melasma. Objective: To research the effectiveness and satisfaction of 5% Kaempferia parviflora extract topical cream for the treatment of melasma. Method: 16 volunteers, female of age between 30 and 65 years old who willingly wanted to get rid of their melasma were collected to participate in split-face double-blinded placebo-controlled trial for 12 weeks. 5% Kaempferia parviflora extract cream and placebo cream were instructed to apply twice daily in designated sides of the face for 12 weeks. Various parameters such as melasma evaluation by dermatologists, MASI score and melanin index were assessed at the start, 4th, 8th and 12th week respectively. Result: Statistically significant results of reduction in MASI score (p-value <0.001) and reduction in mean melanin index (p-value<0.001) were shown for Kaempferia parviflora extract treated side. No side effects were observed throughout the study. Conclusion: Th¬is study statistically demonstrated that Kaempferia parviflora extract reduced melanin production more than placebo cream when it is applied topically with no harmful side effects. So, 5% Kaempferia parviflora could be safe, effective and can be used as an alternative for the treatment of melasma.

Mae Fah Luang University. Learning Resources and Educational Media Center

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Thamthiwat Nararatwanchai

Role: Advisor

Created: 2021

Modified: 2021-12-15

Issued: 2021-12-15

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: WR140 O414s 2020

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

ลำดับที่.	ชื่อแฟ้มข้อมูล	ขนาดแฟ้มข้อมูล	จำนวนเข้าถึง	วัน-เวลาเข้าถึงล่าสุด
1	Okkar Kyaw Khant.pdf	41.59 MB	29	2025-05-04 08:45:57

ใช้เวลา

0.028714 วินาที