Preliminary study of FGF-23 level in post-operative parathyroid glands of renal hyperparathyroidism patients

Name: Narongkhet Leekatesarakorn

keyword: End stage renal disease (ESRD)

Othors: Hyperparathyroidism -- Therapy

; Renal hyperparathyroidism

; Parathyroidectomy

; Fibroblast growth factor 23 (FGF-23)

; Kidney disease

Abstract: Renal hyperparathyroidism is a common complication in patients with the end stage renal disease (ESRD), accelerated by hyperphosphatemia. Fibroblast Growth Factor 23 (FGF-23) has emerged as an important phosphorus-regulating protein for renal phosphate-wasting disorders. In ESRD patients, FGF-23 levels rise with declining kidney function. This study aims to determine the levels of circulating FGF-23 after total surgical removal parathyroid glands in ESRD patients by time dependent. Thirty patients with marked renal hyperparathyroidism were enrolled. All underwent parathyroidectomy and their FGF-23 levels were measured at 0, 10, 20, 30, and 40 minutes after parathyroidectomy by means of ELISA assays. Biochemical data including the result of calcium (Ca), phosphate (PO4), and parathyroid hormone (PTH) has been collected from medical records. FGF-23 levels was significantly decreased at 20 minutes after total parathyroidectomy (p<0.05). FGF-23 levels at 0 and 20 minutes was significantly correlated (p<0.05) with Ca, PO4, and PTH levels. The complete ablation of progressive parathyroid glands significantly reduces circulating FGF-23 levels at 20 minutes. FGF-23 levels correlated positively with serum Ca, PO4, and PTH values in ESRD patients with secondary hyperparathyroidism. These finding suggest that parathyroidectomy, together with hyperphophatemia, affect FGF-23 metabolism in ESRD patients. FGF-23 may be as the predictive data for monitoring the successful treatment for endocrinologist and surgeon

Thammasat University. Thammasat University Library

Address: BANGKOK

Email: preserv@tu.ac.th

Name: Narisa Kengtrong Bordeerat

Role: advisor

Created: 2015

Modified: 2021-08-30

Issued: 2021-08-30

วิทยานิพนธ์/Thesis

application/pdf

DOI: 10.14457/TU.the.2015.928

eng

DegreeName: Master of Medical Technology

Level: Master's Degree

Descipline: Medical Technology

Grantor: Thammasat University

©copyrights Thammasat University

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