Efficacy of tranexamic acid intradermal microinjections reducing risk of postinflammatory hyperpigmentation after Q-switched Nd : YAG laser for the treatment of solar lentigines

Name: Rattima Srieakpanit

keyword: Tranexamic acid

LCSH: Laser therapy

; Solar lentigo

; Postinflammatory hyperpigmentation

; Q-switched 532-nm Nd : YAG laser

Abstract: Background: Postinflammatory hyperpigmentation (PIH) after solar lentigines removal with 532-nm Q-Switched (QS) Nd: YAG laser is a major concerned cosmetic side effect especially in the patients with darker skin type. Many studies have the efforts to prevent PIH after laser treatment. But the highly effective results could not be detected. Objectives: The purpose of this study was to evaluate the efficacy and side effects of tranexamic acid (TA) intradermal (ID) microinjections reduction risk of PIH after 532-nm QS Nd: YAG laser for the treatment of solar lentigines. Methods: Twenty-five patients with fifty solar lentigines were received 532-nm QS Nd: YAG laser treatment. After the laser treatment, one random lesion in each patient was intradermally injected with 50 mg/mL of TA. Another lesion was intradermally injected with normal saline as control group. Pigmentation was measured by the mexameter as melanin index (MI) and erythema index (EI) at the baseline, week 2, 4, 8 and 12. Photograph evaluation in clearing of pigmentation and severity of PIH by two independent dermatologists was evaluated at baseline, week 2, 4, 8 and 12. The patients evaluated patients’ self-improvement score and overall satisfaction at week 2, 4, 8 and 12. Results: Mean MI at the end of study was statistically significant decreased from 339.71 + 85.57 to 312.89 + 73.22 (P=0.009) and from 323.83 + 67.51 to 300.12 + 67.79 (P<0.001) in TA and control groups respectively. There was statistically significant in reduction of mean MI at week 4 compared with baseline between two groups (P=0.025). The same as mean MI, there was statistically significant in reduction of mean EI at week 4 compared with baseline between two groups (P=0.030). Overall incidence of PIH was 28%. Most difference of incidence of PIH showed at week 4 (16%). The degree of intensity and extension of PIH in TA group were less severe and widespread than control group. Although, there were no statistically significant in severity of PIH between two groups through the period of study. The side effects of TA were minimal. Two sujects from TA group reported immediate burning sensation that can resolve within an hour without any treatment. Conclusions: A single dose of 50 mg/mL of ID TA injection can prevent PIH at week 4 after the 532-nm QS Nd: YAG laser for the treatment of solar lentigines. And this method can cause minimal side effects

Thammasat University. Thammasat University Library

Address: BANGKOK

Email: preserv@tu.ac.th

Name: Punyapats Sirithanabadeekul

Role: advisor

Name: Puangpaka Jaiyao

Role: co-advisor

Created: 2016

Modified: 2021-05-31

Issued: 2021-05-31

วิทยานิพนธ์/Thesis

application/pdf

DOI: 10.14457/TU.the.2016.550

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Thammasat University

©copyrights Thammasat University

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