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May Thinn Kyi. A Split-face double-blind randomized placebo-controlled trial of the efficacy of kakadu plum extract for reduction of periorbital wrinkles. Master's Degree(Dermatology). Mae Fah Luang University. Learning Resources and Educational Media Center. : Mae Fah Luang University, 2021.
A Split-face double-blind randomized placebo-controlled trial of the efficacy of kakadu plum extract for reduction of periorbital wrinkles
Name: May Thinn Kyi
Organization :
Mae Fah Luang University
keyword:
Terminalia ferdinandiana
ThaSH:
Aging
-- Prevention
;
Wrinkle
Abstract:
Background: Periorbital wrinkles result from both intrinsic and extrinsic aging. To combat aging and treat wrinkles, antioxidants play an important role by decreasing oxidative stress. Kakadu plum (Terminalia ferdinandiana) extract is well known for its great amount of vitamin C as main ingredient which can scavenge reactive oxygen species (ROS) and give anti-aging effects.
Objective: To study effectiveness and satisfaction of Kakadu plum extract to reduce periorbital wrinkles
Method: 17 volunteers, both male and female of age between 25 and 60 years old were collected to participate in split-face placebo-controlled trial for 12 weeks. 10% Terminalia ferdinandiana extract cream and placebo cream were instructed to apply twice daily to periorbital area for 12 weeks. Various parameters such as skin elasticity, hydration, transepidermal water loss (TEWL) and wrinkle evaluation by dermatologists were assessed at the start, 4th, 8th and 12th week respectively.
Result: Statistically significant results of better elasticity (p-value <0.001 for both crows feet area and undereye area) and better hydration (p-value <0.001 for both crows feet area and undereye area) were shown for Terminalia ferdinandiana treated side at 8th and 12th week. For skin barrier, TEWL was significantly decreased (p-value <0.001 for both crows feet area and undereye area) in kakadu plum side.
Conclusion: This study statistically demonstrated that Kakadu plum extract reduced periorbital wrinkles more than placebo cream when it is applied topically with no harmful side effects. So, 10% Terminalia ferdinandiana could be safe and effective to reduce periorbital wrinkles.
Mae Fah Luang University. Learning Resources and Educational Media Center
Address:
CHIANG RAI
Email:
library@mfu.ac.th
Name: Atchima Suwanchinda
Role:
Advisor
Created:
2021
Modified:
2021-03-08
Issued:
2021-03-08
วิทยานิพนธ์/Thesis
application/pdf
CallNumber:
Thesis WR102 M466s 2019
eng
Level: Master's Degree
Descipline: Dermatology
Grantor: Mae Fah Luang University
©copyrights Mae Fah Luang University
RightsAccess:
ใช้เวลา
0.030823 วินาที
May Thinn Kyi
| Title | Contributor | Type |
|---|---|---|
| A Split-face double-blind randomized placebo-controlled trial of the efficacy of kakadu plum extract for reduction of periorbital wrinkles
มหาวิทยาลัยแม่ฟ้าหลวง May Thinn Kyi | Atchima Suwanchinda | วิทยานิพนธ์/Thesis |
Atchima Suwanchinda
| Title | Creator | Type and Date Create |
|---|---|---|
| Safety and efficacy of continuous macro focused scanning ultrasound for abdominal subcutaneous adipose tissue reduction
มหาวิทยาลัยแม่ฟ้าหลวง Atchima Suwanchinda, M. D. | Chalida Phoobangkerdphol | วิทยานิพนธ์/Thesis |
| The anti-inflammatory effect of 0.8% curcuma longa gel on the treatment of plaque type psoriasis
มหาวิทยาลัยแม่ฟ้าหลวง Atchima Suwanchinda | Min, Thin Zar Soe | วิทยานิพนธ์/Thesis |
| A Split-face double-blind randomized placebo-controlled trial of the efficacy of kakadu plum extract for reduction of periorbital wrinkles
มหาวิทยาลัยแม่ฟ้าหลวง Atchima Suwanchinda | May Thinn Kyi | วิทยานิพนธ์/Thesis |