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Sunatda Arayachukeat. Stability enhancement of all-trans retinyl acetate through Nanoencapsulation. Master's Degree(Petrochemistry and Polymer Science). Chulalongkorn University. Office of Academic Resources. : Chulalongkorn University, 2009.
Stability enhancement of all-trans retinyl acetate through Nanoencapsulation
การเพิ่มความเสถียรภาพของออล-ทรานส์เรทินิลแอซีเทตด้วยนาโนเอ็นแคปซูเลชั
Name: Sunatda Arayachukeat
LCSH:
Nanoencapsulation
Abstract:
In this work, encapsulation of all-trans retinyl acetate was investigated using appropriate polymer. The result showed that ATRA-encapsulated poly(ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC) nanoparticles gave the particle size of 113.2 ± 27.1 nm. The encapsulation efficiency was 77.9 ± 2.5% at ATRA loading of 21.06 ± 0.1%. The stability study under light-proof condition and when exposed to 45.9 J/cm2 of UVA radiation indicated ~40% and ~36% higher stability of the encapsulated ATRA over free ATRA, respectively. Penetration study with Franz diffusion cell revealed that the encapsulated particles could not transdermally penetrate across the baby mouse skin. Further investigation using confocal fluorescent laser scanning microscope indicated that hair follicle was the skin penetrating route of the particles. In addition, the accumulated particles at the hair follicles released ATRA out into the surrounding tissue.
Abstract:
In this work, encapsulation of all-trans retinyl acetate was investigated using appropriate polymer. The result showed that ATRA-encapsulated poly(ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC) nanoparticles gave the particle size of 113.2 ± 27.1 nm. The encapsulation efficiency was 77.9 ± 2.5% at ATRA loading of 21.06 ± 0.1%. The stability study under light-proof condition and when exposed to 45.9 J/cm2 of UVA radiation indicated ~40% and ~36% higher stability of the encapsulated ATRA over free ATRA, respectively. Penetration study with Franz diffusion cell revealed that the encapsulated particles could not transdermally penetrate across the baby mouse skin. Further investigation using confocal fluorescent laser scanning microscope indicated that hair follicle was the skin penetrating route of the particles. In addition, the accumulated particles at the hair follicles released ATRA out into the surrounding tissue.
Chulalongkorn University. Office of Academic Resources
Address:
BANGKOK
Email:
cuir@car.chula.ac.th
Role:
advisor
Created:
2009
Modified:
2020-08-09
Issued:
2020-08-09
วิทยานิพนธ์/Thesis
application/pdf
URL: http://cuir.car.chula.ac.th/handle/123456789/63753
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Petrochemistry and Polymer Science
Grantor: Chulalongkorn University
©copyrights Chulalongkorn University
RightsAccess:
ใช้เวลา
0.031844 วินาที
Sunatda Arayachukeat
| Title | Contributor | Type |
|---|---|---|
| Stability enhancement of all-trans retinyl acetate through Nanoencapsulation
จุฬาลงกรณ์มหาวิทยาลัย Sunatda Arayachukeat | Supason Wanichwecharungruang | วิทยานิพนธ์/Thesis |
| Carbon oxide nanoparticles for controlled delivery of curcumin peptide nucleic acid
จุฬาลงกรณ์มหาวิทยาลัย Sunatda Arayachukeat | Supason Wanichwecharungruang Tanapat Palaga | วิทยานิพนธ์/Thesis |
Supason Wanichwecharungruang