Abstract:
Introduction: At present, there are many treatments of periorbital wrinkle, increase skin moisture and increase skin elasticity. Wan chak mod luk (Curcuma comosa Roxb.) is a Thai phytoestrogen-rich plant which contains substances that can reverse skin aging effect. Phytoestrogen helps enhance the morphology and synthesis of elastic fiber, collagen fiber and hyaluronic acid, resulting in the reduction of periorbital wrinkles and the increase of elasticity and moisture in periorbital and under eye areas.
Objectives to study the efficiency of Curcuma comosa Roxb. Extract on the treatment of periorbital wrinkles. Materials and Methods: Twenty-two Thai female volunteers, age 40-60 years, were recruited to undergo the treatment of periorbital wrinkles. The treatment included applying Wan chak mod luk serum or placebo around the left or right periorbital area twice a day, morning and evening, for 12 weeks. Assessments of wrinkles by Rao-Goldman 5-point visual scoring scale by a researcher, measurement of wrinkles by Visioscan®VC98, measurement moisture by Corneometer CM825 and measurement elasticity by Cutometer MPA580, The evaluation took place at the fallowing stages: Pre-treatment, week4, week8 and week12. Subjects evaluated level of self-assessment after use of the product and assessment of side effects when the research was finished.
Twenty-two Thai females volunteers were completed the study (12 weeks). Group of Wan chak mod luk serum showed statistically significant reduction of wrinkles, and increase skin moisture, skin elasticity at crow feet and undereye area higher than placebo serum group, Participants satisfaction showed the Wan chak mod luk serum and placebo serum can reduce wrinkle, increase skin elasticity, increase skin moisture. Side effects were assessed by questionnaires. No side effect was observed Wan chak mod luk serum may be an alternative medicine for reduce periorbital wrinkles.