Assessment of lipid in liver and serum of overweight persons by proton nuclear magnetic resonance spectroscopy technique

การประเมินระดับไขมันในตับและซีรัมของผู้ที่มีน้ำหนักเกินโดยเทคนิคโปรตอนนิวเคลียร์แมกเนติกเรโซแนนซ์ สเปกโตรสโคปี

Name: Duanghathai Pasanta

ThaSH: X-ray spectroscopy

Classification :.DDC: 537.5352

ThaSH: Protons

Abstract: Obesity and simply being overweight are both associated with non-alcoholic fatty liver disease (NAFLD). Young adults are likely to develop unhealthy lifestyles that can lead to them being overweight and obese. Proton magnetic resonance spectroscopy (1H MRS) is a non-invasive technique for determining liver fat content for young adults. Seventy-eight healthy young adults, between 19-30 years of age participated in this study. This group was then devided into a control group of 39 subjects and 39 subjects being the overweight/obese group (OW/OB group). Biochemical measurements and 1H MRS were performed to assess liver fat content (LFC). LFC was found to be almost three times higher in the OW/OB group when compared to the control group. It was also found that there was a 48.7% incidence rate of NAFLD in the OW/OB group. Blood biochemical measurements showed statistically higher levels of LDL and triglyceride, lower levels of HDL with elevated HbA1c, with fasting glucose also being present in the OW/OB group. BMI was the most significant independent predictor for LFC after adjusting for age and sex (multiple linear regression; β=0.459, p<0.001). This result was consistent with prior NMR serum studies that showed significantly increasing levels of total lipid content and lipids CH3 (LDL+VLDL), lipids CH2 (LDL+VLDL), and CH-CH2= bond of lipid occurring in OW/OB groups. The PLS-DA analysis also revealed that lipids CH2 (LDL+VLDL) and lipids CH3 (LDL+VLDL) occur as metabolites that are important factors that distinguish the OW/OB groups from control groups. Due to the prevalence of high liver fat content in the OW/OB group, it can be proposed that weight gain and obesity is a leading pathogenic mechanism in liver fat accumulation for this age group. These findings further emphasize the importance of BMI as tools for prevention and control of NAFLD in young adults.

Chiang Mai University Library

Address: Chiang Mai

Email: cmulibref@cmu.ac.th

Name: Warayuth Sajomsang

Role: Chairman

Name: Suchart Kothan

Role: Member

Name: Sirirat Chunchcharunee

Role: Member

Name: Montree Tungjai

Role: Member

Created: 2018

Modified: 2020-01-09

Issued: 2020-01-09

วิทยานิพนธ์/Thesis

application/pdf

Th 537.5352 D812A

eng

DegreeName: Master of Science

Grantor: Chiang Mai University

Level: Master's Degree

Descipline: Medical Radiation Sciences

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