Mechanical properties of dissolvable microneedles arrays for transdermal drug delivery

Name: Teeranut Rutwaree

Organization : Chulalongkorn University. Faculty of Science

Name: Supasorn Wanichwecharungruang

Organization : Chulalongkorn University. Faculty of Science

Email : supason.p@chula.ac.th

keyword: Microneedle arrays

LCSH: Transdermal medication

LCSH: Biomedical materials -- Mechanical Properties

Abstract: Dissolvable microneedles have been used for transdermal drug delivery. They are usually fabricated from water-soluble biocompatible materials such as biocompatible polymers and sugars. Here, we have investigated the correlation between hyaluronic acid (HA) polyvinylpyrrolidone (PVP) composite and properties of the fabricated microneedles. Stereomicroscope is used to observe the morphology whereas compression strength of the microneedles was measured by universal testing machine. We observed that the microneedles with high PVP content possessed a higher compressive strength. Dissolution rate of microneedles was measured in situ of the porcine ear skin. The results indicated that the microneedles with high PVP content showed the faster dissolving rate in the porcine ear skin than the microneedles with high HA content

King Mongkut's University of Technology North Bangkok. Central Library

Address: BANGKOK

Email: library@kmutnb.ac.th

Created: 2019

Modified: 2019-10-11

Issued: 2019-10-11

บทความ/Article

application/pdf

BibliograpyCitation : In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn. Pure and Applied Chemistry International Conference 2019 (PACCON 2019) (O11-15). Bangkok : Mahidol University

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