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Puttinan Meepowpan. Structural modification of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Ma-kiang seeds residue of juice industry for use as anticancer agents. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2019.
Structural modification of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Ma-kiang seeds residue of juice industry for use as anticancer agents
Name: Lada Chaichuang
Organization :
Chiang Mai University. Faculty of Science
Name: Neeranuth Intakaew
Organization :
Chiang Mai University. Faculty of Science
Name: Puracheth Rithchumpon
Organization :
Chiang Mai University. Faculty of Science
Name: Puttinan Meepowpan
Organization :
Chiang Mai University. Faculty of Science
Email :
pmeepowpan@gmail.com
LCSH:
Antineoplastic agents
Abstract:
2',4'-Dihydroxy-6′-methoxy-3',5'-dimethylchalcone or DMC was isolated from ethyl acetate crude extract of Ma-kiang seeds (Syzygium nervosum A. Cunn. Ex DC) which was residue from juice industry in Lampang. Then, we modified DMC structure through several reactions, such as methylation, allylation, benzylation and benzoylation. The resulting products consisted of 4'-O-protected chalcone and O-protected flavanone derivatives. Then, the modified products were tested for anticarcinoma activity on P-388 (murine lymphocytic leukemia), MCF-7 (human breast), KB (human oral nasopharyngal) and CL (human large intestine) cancer cell lines. 5-Hydroxy-7-methoxy-6,8-dimethylflavanone exhibited the highest cytotoxicity as ED50 values at 1.10 and 2.17 microgram per mL on P-388 and MCF-7 cell lines, respectively. Moreover, 5,7-dimethoxy-6,8-dimethylflavanone showed the greatest cytotoxicity as ED50, 2.14 and 1.90 microgram per mL as KB and CL cell lines, consecutively. According to the results, O-protected flavanone moiety showed greater cytotoxicity on every carcinoma cell lines than 4′-O-protected chalcone derivatives
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2019
Modified:
2019-10-10
Issued:
2019-10-10
บทความ/Article
application/pdf
BibliograpyCitation :
In Chemical Society of Thailand under the Patronage of Professor Dr. HRH Princess Chulabhorn. Pure and Applied Chemistry International Conference 2019 (PACCON 2019) (OR6-11). Bangkok : Mahidol University
eng
©copyrights King Mongkut's University of Technology North Bangkok
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ใช้เวลา
0.018595 วินาที
Lada Chaichuang
| Title | Contributor | Type |
|---|---|---|
| Structural modification of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Ma-kiang seeds residue of juice industry for use as anticancer agents
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Lada Chaichuang;Neeranuth Intakaew;Puracheth Rithchumpon;Puttinan Meepowpan | บทความ/Article |
Neeranuth Intakaew
| Title | Contributor | Type |
|---|---|---|
| Synthesis of novel enantiomeric hindered acid-anthracene adducts for the absolute configuration assignment of chiral secondary alcohols by 1H NMR
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Puracheth Rithchumpon;Neeranuth Intakaew;Puttinan Meepowpan | บทความ/Article | |
| Structural modification of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Ma-kiang seeds residue of juice industry for use as anticancer agents
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Lada Chaichuang;Neeranuth Intakaew;Puracheth Rithchumpon;Puttinan Meepowpan | บทความ/Article | |
| Syntheses of enantiomeric acidanthracene adducts for absolute configuration determination of chiral secondary alcoholsby 1h-nmr technique
มหาวิทยาลัยเชียงใหม่ Neeranuth intakaew | Tienthong Thongpanchang Puttinan Meepowpan Winita Punyodom Nuchnipa Nuntawong Nawee Kungwan | วิทยานิพนธ์/Thesis |
Puracheth Rithchumpon
| Title | Contributor | Type |
|---|---|---|
| Synthesis of novel enantiomeric hindered acid-anthracene adducts for the absolute configuration assignment of chiral secondary alcohols by 1H NMR
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Puracheth Rithchumpon;Neeranuth Intakaew;Puttinan Meepowpan | บทความ/Article | |
| Structural modification of 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Ma-kiang seeds residue of juice industry for use as anticancer agents
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Lada Chaichuang;Neeranuth Intakaew;Puracheth Rithchumpon;Puttinan Meepowpan | บทความ/Article |
Puttinan Meepowpan