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Sakhiran Sakulwech. Development of quaternized cyclodextrin grafted chitosan and hyaluronic acid nanoparticles as a dermal delivery carrier. Master's Degree(Cosmetic Science). Mae Fah Luang University. The Learning Resources and Education Media Center. : , 2018.
Development of quaternized cyclodextrin grafted chitosan and hyaluronic acid nanoparticles as a dermal delivery carrier
Name: Sakhiran Sakulwech
Address:
333 Moo1, Thasud, Muang, Chiang Rai 57100
Organization :
Mae Fah Luang University. School of Cosmetic Science. Cosmetic Science
Email :
ask.library@mfu.ac.th
keyword:
Hyaluronic acid
LCSH:
Chitosan
Classification :.LCCS: QU83
LCSH:
Hyaluronic Acid
-- therapeutic use
LCSH:
Nanoparticles
LCSH:
Hyaluronic Acid
-- chemistry
Abstract:
The aim of this study was to prepare nano-carrier systems of quaternized cyclodextrin-grafted chitosan (QCD-g-CS) associated with three different molecular weights of hyaluronic acid (HA) in various molar ratios. The QCD-g-CS complexes with 1.5 mole of low molecular weight HA (LHA_1.5) and the QCD-g-CS complexes with 0.3 mole of medium molecular weight HA (MHA_0.3) were the significantly smallest complexes (264.30 ± 1.51 and 235.63 ± 21.89 nm, respectively) with zeta potential of 13.53 to 16.07 mV and narrow size distributor (PDI less than 0.25). Those selected complexes, which provided low particles size (less than 300 nm) and positive charge, exhibited high association efficiency (more than 80%) and loading efficiency of 10.85 to 11.55%. The ionic conjugations of the carboxylic moieties of HA and the amides of QCD-g-CS were confirmed by FTIR. The condensed spherical micelle shapes of both selected nanoparticles were observed by TEM. The released HA from LHA_1.5 (42.40 ± 0.6 %) was greater than that from MHA_0.3 (21.78 ± 0.16 %), and the release mechanism was by limited diffusion kinetics. LHA_1.5 showed the deeper penetration into skin layer compared to LHA by ex vivo assay. The clinical study was showed that LHA_1.5 complexes provided better moisturizing efficacy and anti-wrinkle properties. These developed nano-complexes can be used as cosmetic active ingredient for anti-aging treatment.
Mae Fah Luang University. The Learning Resources and Education Media Center
Address:
Chiang Rai
Email:
library@mfu.ac.th
Role:
Advisor
Name: Nattaya Lourith
Role:
Co-Advisor
Email :
ask.library@mfu.ac.th
Name: Uracha Ruktanonchai
Role:
Co-Advisor
Email :
ask.library@mfu.ac.th
Created:
2018
Issued:
2562
Modified:
2020-05-12
Issued:
2019-09-09
วิทยานิพนธ์/Thesis
application/pdf
CallNumber:
Thesis QU83 S158d 2018
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Cosmetic Science
©copyrights Mae Fah Luang University
RightsAccess:
ใช้เวลา
0.036004 วินาที
Sakhiran Sakulwech
| Title | Contributor | Type |
|---|---|---|
| Validated determination of hyaluronic acid by UPLC-UV for pharmaceutical products
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Sakhiran Sakulwech;Mayuree Kanlayavattanakul;Nattaya Lourith;Uracha Ruktanonchai | บทความ/Article | |
| Development of quaternized cyclodextrin grafted chitosan and hyaluronic acid nanoparticles as a dermal delivery carrier
มหาวิทยาลัยแม่ฟ้าหลวง Sakhiran Sakulwech | Mayuree Kanlayavattanakul Nattaya Lourith Uracha Ruktanonchai | วิทยานิพนธ์/Thesis |
Mayuree Kanlayavattanakul
| Title | Creator | Type and Date Create |
|---|---|---|
| Antioxidant activity of chemical constituents from Kaempferia parviflora Wall ex Baker
มหาวิทยาลัยเชียงใหม่ Sunee Chansakaow;Chaiyavat Chaiyasut;Ampai Phrutivorapongkul;Mayuree Kanlayavattanakul | Kamolporn Panyakard | วิทยานิพนธ์/Thesis |
| Chemical constituents and biological activities of some combretum species in Northern Thailand
มหาวิทยาลัยเชียงใหม่ Mayuree Kanlayavattanakul;Sunee Chansak;Dammrong Santiarworn;Sompom Putiyanan;Surapol Natakankitkul;Sasithom Sirilun | Wimaluk Nopsiri | วิทยานิพนธ์/Thesis |
| Decolorization of malva nut gum for skin moisturizing cosmetics
มหาวิทยาลัยแม่ฟ้าหลวง Assoc. Prof. Mayuree Kanlayavattanakul, Ph. D.;Asst. Prof. Nattaya Lourith, Ph. D. | Phichada But-amkha | วิทยานิพนธ์/Thesis |
| Development of quaternized cyclodextrin grafted chitosan and hyaluronic acid nanoparticles as a dermal delivery carrier
มหาวิทยาลัยแม่ฟ้าหลวง Mayuree Kanlayavattanakul;Nattaya Lourith;Uracha Ruktanonchai | Sakhiran Sakulwech | วิทยานิพนธ์/Thesis |
| Preparation of microemulsion containing sacha inchi seed oil
มหาวิทยาลัยแม่ฟ้าหลวง Mayuree Kanlayavattanakul;Suvimol Surassmo | Kitithat Charastrakul | วิทยานิพนธ์/Thesis |
Nattaya Lourith
| Title | Creator | Type and Date Create |
|---|---|---|
| Decolorization of malva nut gum for skin moisturizing cosmetics
มหาวิทยาลัยแม่ฟ้าหลวง Assoc. Prof. Mayuree Kanlayavattanakul, Ph. D.;Asst. Prof. Nattaya Lourith, Ph. D. | Phichada But-amkha | วิทยานิพนธ์/Thesis |
| Coupling products of the selected phenolics for sunscreen foundation prototype
มหาวิทยาลัยแม่ฟ้าหลวง Asst. Prof. Nattaya Lourith, Ph. D. | Hadi, Nicholas | วิทยานิพนธ์/Thesis |
| Development of quaternized cyclodextrin grafted chitosan and hyaluronic acid nanoparticles as a dermal delivery carrier
มหาวิทยาลัยแม่ฟ้าหลวง Mayuree Kanlayavattanakul;Nattaya Lourith;Uracha Ruktanonchai | Sakhiran Sakulwech | วิทยานิพนธ์/Thesis |
| Preparation and characterization of rice bran Oil-Silver nanoparticles for UV protection
มหาวิทยาลัยแม่ฟ้าหลวง Nattaya Lourith | Puntira Khatsri | วิทยานิพนธ์/Thesis |
Uracha Ruktanonchai