The anti-inflammatory effect of 0.8% curcuma longa gel on the treatment of plaque type psoriasis

Anti-inflammatory effect of 0.8% curcuma longa gel on the treatment of plaque type psoriasis

Name: Min, Thin Zar Soe

Address: 333 Moo1, Thasud, Muang, Chiang Rai 57100

Organization : Mae Fah Luang University. School of Anti-Aging and Regenerative Medicine. Dermatology

Email : ask.library@mfu.ac.th

keyword: Psoriasis

LCSH: Psoriasis -- therapy

Classification :.LCCS: WR205

LCSH: Plants, Medicinal

LCSH: Curcumin

Abstract: Background: Psoriasis is a chronic inflammatory and proliferative condition of the skin, associated with systemic manifestations in many organ systems. The most characteristic lesions consist of red, scaly, sharply demarcated, indurated plaques, present particularly over the extensor surfaces and scalp.Curcumin is a polyphenol compound derived from turmeric spice (“Curcuma longa”), of the ginger Zinzigiberaceae family, which is commonly used in many alternative methods such as food additive, make-up and as herbal medicine product in the treatment of chronic inflammatory diseases. Objective: To study the efficacy and satisfactory evaluation of 0.8% Curcuma longa gel for treatment of plaque type psoriasis. Method: This study is randomized, prospective intra-individual, right–left comparative, placebo-controlled, double-blind clinical trial.10 male and 6 female volunteers were enrolled according to inclusion and exclusion criteria.0.8% Curcuma longa (turmeric) gel and standard gel (same consistency, smell and color) were applied by on either right or left side of the psoriatic area by double blind randomization method. The psoriatic condition will be measured using mPASI (Modified Psoriasis Area and Severity Index) and SELS (Surface evaluation of living skin) parameters using Visioscan® VC 98 at both side at the base line and then follow up for 4 weeks interval for 3 times. (4th, 8th, 12th week). The data collected from each follow up were statistically analyzed by SPSS. Results: The comparison of mPASI between the follow-up phase for both groups, it is found that the 0.8% Curcuma longa gel were mean of mPASI statistically significant decrease between the follow-up phase (p<0.001). According the comparison between SELS parameter between both groups, there is statistically significant decrease in Scaliness, Roughness and Wrinkles of the surface of the psoriatic area (p<0.001). The smoothness of the area significantly higher than the standard gel base group at follow-up 4th and 12th week (p=0.048 and p=0.002, respectively). Conclusion: 0.8% Curcuma longa gel show significant reduction in PASI score, roughness, scaliness and wrinkles compare to the standard gel group. And it also showed improvement in smoothness during the following up period. 81% of the patients were satisfied with the results. No side effects were noted with the Curcuma longa gel during the study period.

Mae Fah Luang University. The Learning Resources and Education Media Center

Address: Chiang Rai

Email: library@mfu.ac.th

Name: Atchima Suwanchinda

Role: Advisor

Email : ask.library@mfu.ac.th

Created: 2018

Issued: 2562

Modified: 2020-05-07

Issued: 2019-08-28

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis WR205 M663a 2018

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

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