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Tirayut Vilaivan. Gold nanoparticles and pyrrolidinyl peptide nucleic acid-based platform for the detection of RNA. (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2018.
Gold nanoparticles and pyrrolidinyl peptide nucleic acid-based platform for the detection of RNA
Name: Kriangsak Faikhruea
Organization :
Chulalongkorn University. Faculty of Science
Name: Tirayut Vilaivan
Organization :
Chulalongkorn University. Faculty of Science
Email :
vtirayut@chula.ac.th
keyword:
Peptide Nucleic Acids
LCSH:
Ribonucleic acid
Abstract:
Following our previous success in the development of a gold nanoparticle and PNAbased
dual-mode fluorescence and colorimetric platform for DNA detection, the applicability
of the system for detection of RNA was further evaluated. This platform consists of citratecapped
gold nanoparticles (AuNPs) and pyrrolidinyl peptide nucleic acid (acpcPNA) a
conformationally constrained DNA mimic with neutral-charged backbone consisting of
nucleobase-modified proline and cyclic B-amino acid. In fluorescence detection mode, the
electrostatic adsorption of positively-charged lysine-modified fluorescein-labeled PNA on the
AuNPs surface resulted in quenching of the fluorescence signal, which was selectively
restored when the complementary RNA was added. For colorimetric detection mode,
positive-charged single-stranded PNA induced the aggregation of AuNPs leading to a
pronounced color change from red to blue. The aggregation was suppressed in the presence
of the complementary RNA. This platform is therefore a potentially versatile and useful tool
for RNA detection for various application. This was showcased by the detection of miRNA
which is an important biomarker for cancer diagnosis.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2018
Modified:
2019-07-22
Issued:
2019-07-12
บทความ/Article
application/pdf
BibliograpyCitation :
In Prince of Songkla University Faculty of Science. Pure and Applied Chemistry International Conference (PACCON 2018) (pp.OR92-OR97). Songkla : Prince of Songkla University
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
0.032886 วินาที
Kriangsak Faikhruea
| Title | Contributor | Type |
|---|---|---|
| Gold nanoparticles and pyrrolidinyl peptide nucleic acid-based platform for the detection of RNA
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kriangsak Faikhruea;Tirayut Vilaivan | บทความ/Article | |
| Sequence specific nucleic acid sensing by pyrrolidinyl peptide nucleic acid and nanomaterials
จุฬาลงกรณ์มหาวิทยาลัย Kriangsak Faikhruea | Tirayut Vilaivan | วิทยานิพนธ์/Thesis |
| DNA-templated synthesis of cationic styryl dyes
จุฬาลงกรณ์มหาวิทยาลัย Kriangsak Faikhruea | Tirayut Vilaivan | วิทยานิพนธ์/Thesis |
Tirayut Vilaivan
| Title | Contributor | Type |
|---|---|---|
| Synthesis of hydrophobically-modified poly(ethyleneimine) as surfactant for cationic CdSe/ZnS quantum dots with high colloidal stability
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Jamornpan Yangcharoenyuenyong;Tirayut Vilaivan;Numpon Insin | บทความ/Article | |
| Gold nanoparticles and pyrrolidinyl peptide nucleic acid-based platform for the detection of RNA
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Kriangsak Faikhruea;Tirayut Vilaivan | บทความ/Article | |
| Ozonolysis of olefins with household ozone generator
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