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Chutima Jiarpinitnun. Hybrid molecule: combination between sulfonamides and trimethoprim to inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA). (). King Mongkut's University of Technology North Bangkok. Central Library. : , 2018.
Hybrid molecule: combination between sulfonamides and trimethoprim to inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA)
Name: Taechin Nowwarat
Organization :
Mahidol University. Faculty of Science
Name: Napon Nilchan
Organization :
Mahidol University. Faculty of Science
Name: Chutima Jiarpinitnun
Organization :
Mahidol University. Faculty of Science
Email :
chutima.jia@mahidol.ac.th
LCSH:
Sulfonamides
LCSH:
Trimethoprim
LCSH:
Gram-positive bacteria
Abstract:
The pathogenic Gram-positive bacteria Staphylococcus aureus (S. aureus) causes
global health concerns due to its rapid development of resistance towards antibiotics used.
The emergence of antibiotic resistance has complicated the treatment of S. aureus infections,
especially, methicillin-resistant S. aureus (MRSA) that acquired resistance to beta-lactam
antibiotics such as penicillin. Sulfonamide antibiotics have been used to treat S. aureus and
MRSA infections. Sulfa-drug can be used as single-entity drug or in combination with
trimethoprim. However, the rise of sulfa-resistance and trimethoprim-resistance has led to a
decrease in clinical uses. Several studies have exploited the dimerization concept to enhance
efficacy and to overcome bacterial resistance. Here in, we reported the rationally design and
synthesis of a sulfonamide-trimethoprim hybrid. The hybrid ligand was simply designed to
covalently linked trimethoprim and sulfonamide adducts via C-C bond formation. The hybrid
molecule was evaluated for their efficacy against S. aureus control strains and globally
epidemic MRSA strain SF8300. Based on Kirby-Bauer disk diffusion assay, our results
promisingly indicated that the hybrid molecule could successfully inhibit growth of all S.
aureus strains, suggesting that the hybrid compound was effective against antibiotic resistant
strains of S. aureus.
King Mongkut's University of Technology North Bangkok. Central Library
Address:
BANGKOK
Email:
library@kmutnb.ac.th
Created:
2018
Modified:
2019-07-22
Issued:
2019-07-12
บทความ/Article
application/pdf
BibliograpyCitation :
In Prince of Songkla University Faculty of Science. Pure and Applied Chemistry International Conference (PACCON 2018) (pp.OR53-OR58). Songkla : Prince of Songkla University
eng
©copyrights King Mongkut's University of Technology North Bangkok
RightsAccess:
ใช้เวลา
-0.964244 วินาที
Taechin Nowwarat
| Title | Contributor | Type |
|---|---|---|
| Hybrid molecule: combination between sulfonamides and trimethoprim to inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA)
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Taechin Nowwarat;Napon Nilchan;Chutima Jiarpinitnun | บทความ/Article |
Napon Nilchan
| Title | Contributor | Type |
|---|---|---|
| Hybrid molecule: combination between sulfonamides and trimethoprim to inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA)
มหาวิทยาลัยเทคโนโลยีพระจอมเกล้าพระนครเหนือ Taechin Nowwarat;Napon Nilchan;Chutima Jiarpinitnun | บทความ/Article |
Chutima Jiarpinitnun
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|---|---|---|
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