Clinical study of ablative fractional carbon dioxide laser with topical epidermal growth factor for facial rejuvenation

Name: Chatchalee Patthanapalakornskul

Organization : Mae Fah Luang University

keyword: Carbon dioxide laser

LCSH: Laser Therapy

Classification :.LCCS: WR650

LCSH: Dermatology

LCSH: Rejuvenation

LCSH: Skin Diseases

LCSH: Epidermal Growth Factor -- analysis

Abstract: Background: Utilizing advanced laser technology, the ablative fractional thermolysis has shown acceptable clinical outcomes with less down time for patients and fewer overall adverse effects, the down time associated with ablative fractional laser treatment still remains a problem. How to reduce down time of fractional CO2 laser, while enhancing its rejuvenation effect, has become one hot topic in dermatological research field. Therefore, the application of ablative fractional CO2 lasers with topical epidermal growth factor are considered synergistic effect for facial rejuvenation. Objective: To study about clinical efficacy, complications and subjects satisfaction of ablative fractional CO2 laser treatments with topical epidermal growth factor for facial rejuvenation. Methods: Fourteen volunteers who want to do facial rejuvenation were recruited. All subjects received two full-face sessions of fractional CO2 laser treatment every four weeks. Topical epidermal growth factor was applied on full face after laser peel. All subjects had been taken a photograph by VISIA®. Clinical improvement of skin texture was evaluated by two independent physicians at 1 and 2 months after the last treatment. Other parameters measured by cutometer and tewameter had been recorded. Side effects were recorded after each treatment session. Satisfaction scores were surveyed after 2 month post-treatment. Results: Mean of improvement scale from physician were 1.00 (SD = 0.78) at 1-month follow-up, 1.46 (SD = 0.60) at 2-month follow-up. There were significant difference of mean improvement score at 1 and 2 months follow-up (p=0.008). From the study, the mean“R2” ratio scores changed from 0.6604 at baseline to 0.7559 at 1month follow-up and 0.7900 at 2month follow-up. There were both statistical significance in ability of returning at 1 month (-0.0955 ± 0.0496; p<0.001) and 2 month follow-ups (-0.1296 ± 0.0532; p<0.001) compare to baseline. The mean TEWL ratio changed from 5.70 at baseline to 5.53 at 1month follow-up and 5.19 at 2month follow-up. Comparison transepidermal water loss between baseline and1 month follow-ups, we found no statistically difference between this period (0.17 ± 0.31; p=0.053). Whereas there were statistically difference transepidermal water loss between baseline and 2 month follow-ups(0.52 ± 0.34; p<0.001). Most of subjects (85.7%) satisfied the result of treatment. The highest incidence of side effects was immediate erythema occurred in all subjects (100%). None of volunteers indicated serious side effects. Conclusion: The combination of ablative fractional CO2 laser with topical epidermal growth factor can be effective treatments for facial rejuvenation.

Mae Fah Luang University

Address: CHIANG RAI

Email: library@mfu.ac.th

Name: Paisal Rummaneethorn

Role: Advisor

Created: 2017

Issued: 2561

Modified: 2020-01-21

Issued: 2018-09-12

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis WR650 C492c 2017

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

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