แจ้งเอกสารไม่ครบถ้วน, ไม่ตรงกับชื่อเรื่อง หรือมีข้อผิดพลาดเกี่ยวกับเอกสาร ติดต่อที่นี่ ==>
หากไม่มีอีเมลผู้รับให้กรอก thailis-noc@uni.net.th
หากไม่มีอีเมลผู้รับให้กรอก thailis-noc@uni.net.th
Chaiyasith Lechanavanishphan. Effects of aerobic exercise training on cellular immunity. Master's Degree(Physiology of Exercise). Mahidol University. Mahidol University Library and Knowledge Center. : Mahidol University, 1987.
Effects of aerobic exercise training on cellular immunity
ผลของการฝึกออกกำลังกายแบบอากาศนิยมต่อเซลล์ในระบบภูมิคุ้มกันของร่างกาย
MeSH:
Aerobic exercises.
MeSH:
Immunity, Cellular
MeSH:
Physical fitness
Abstract:
The effects of strenuous and aerobic exercises on peripheral subsets of T lymphocytes, helper and suppressor cells and their ratio, including hematological parameters were investigated into 10 male students from Chulalongkorn University in study I and 28 male paramedical students of Mahidol University in study II. The subjects in study I and II were similar socio-economic status and age matching. Hear rate was continuously computed by electrocardiogram. Subsets of T lymphocytes were identified by using an indirect immunofluorscence technique with monoclonal antibodies (Behringwerke, Germany). In study I, athletic and sedentary students were randomly selected into respective athletic group (AG) and non-athletic group (NG). Each group consisted of 5 subjects who performed on a bicycle ergometer one hour with 70% MHR [0.7 (MHR-RHR)+RHR] or 65% maximum oxygen consumption (VO2max.). The VO2 max (mean±SEM) of AG group (57.5±3.6 ml/min/kg) was initially higher than that of NG group (39.2±1.3). The subsets of T lymphocytes and hematological parameters were determined from fasting blood samples taken early morning and immediately after strenuous exercise. Leukocytosis occured after exercise approximately 40% in both AG and NG groups accompanied with a large neutrophilia and a lymphocytosis but no change in percent hematocrit. Acute neutrophilia may due to redistribution of cell from marginal pool. Before exercise, peripheral subsets of T cells, %T(,4), %T(,8), T(,4)/T(,8) ratio, abs T(,4), and abs T(,8) (mean±SEM) of AG and NG groups were 49.8±3.9%, 28.5±2.8%, 1.88±0.36, 1062±67 cells/mm(3) and 622±77 cells/mm(3), and 36.1±2.2%, 35.1±2.8%, 1.04±0.08, 774±33 cells/mm(3) and 756±51 cells/mm(3), respectively. In after exercise, those of T cells in AG and NG groups were 39.9±4.2%, 37.4(+2.6%, 1.09+0.16, 1041+130 cells/mm(3) and 1000±38 cells/mm(3), and 28.9±0.9%, 40.0±2.8%, 0.73±0.04, 767±42 cells/mm(3) and 1044±75 cells/mm(3), respectively. Therefore, helper/suppressor (H/S) cells ratio of AG group before exercise was significantly greater than that of NG group. After exercise, the H/S ratio of AG and NG groups were significantly decreased by the decrease in percent helper (%T(,4)) and increase in percent suppressor (%T(,8)) cells of total lymphocytes. This may due to the marked elevation of absolute number of suppressor cells (abs T(,8)) of both groups which also associate with a squeeze of spleen and lymphocytosis. However, the imbalance of T cell subsets indicate that strenuous exercise may lead to defect in cellular immune response within one hour after exercise. The 28 paramedical students, 20-23 years of age, were divided into 17 subjects of exercise training group (ET) and 11 subjects of control group. Only ET group was trained throughout 16 wks based on aerobic exercise program (70% MHR, 20 min/day and 3 days/wk) according to karvonen, M.J. (1957). All parameters were determined at rest in each period of time at the beginning, 8(th) wk and 16(th) wk. The exercise program provided sufficient improvement in physical fitness by increasing 30% VO2 max. Resting leukocyte count in ET group after training was significantly decreased by 10% resulted from decrease neutrophils. The subsets of T cells, %T(,4), %T(,8), H/S ratio, abs T(,4) and abs T(,8) of ET were 43.5±1.6%, 38.6±1.0%, 1.13±0.05, 1143±66 cells/mm(3) and 1010±48 cells/mm(3) at the beginning, and 45.0±1.6%, 35.4±0.9%, 1.28±0.05, 1158±83 cells/mm(3) and 913±61 cells mm(3) at 8(th) wk, and 45.6±1.5%, 34.8±0.8%, 1.32±0.06, 1207±86 cells/mm(3) and 916±53 cells/mm(3) at 16(th) wk, respectively. In contrast to the study I, H/S ratio of ET group was significantly increased which corresponsed in a tendency to increase in helper cells and a significant decrease in suppressor cells. However, VO2 max in ET group has no correlation with its H/S ratio (R(2) = 0.07). Thus, the modification of cellular immune response should depend upon level of exercise (intensity, duration and frequency). Finally, the increased resting H/S ratio of aerobic training may enhance cellular immune response for better health.
Mahidol University. Mahidol University Library and Knowledge Center
Address:
NAKHONPATHOM
Email:
liwww@mahidol.ac.th
Name: Thirayudh Glinsukon
Role:
Thesis Advisors
Name: Somnate Boonpucknavig
Role:
Thesis Advisors
Created:
1987
Modified:
2018-03-07
Issued:
2018-03-07
วิทยานิพนธ์/Thesis
application/pdf
eng
DegreeName: Master of Science
Level: Master's Degree
Descipline: Physiology of Exercise
Grantor: Mahidol University
ใช้เวลา
0.443357 วินาที
Chaiyasith Lechanavanishphan
| Title | Contributor | Type |
|---|---|---|
| Effects of aerobic exercise training on cellular immunity
มหาวิทยาลัยมหิดล Chaiyasith Lechanavanishphan | Thirayudh Glinsukon Somnate Boonpucknavig | วิทยานิพนธ์/Thesis |
Thirayudh Glinsukon
Somnate Boonpucknavig