The effectiveness of 5% nelumbo nucifera gaertn. extract cream for facial whitening in Thais

Effectiveness of 5% nelumbo nucifera gaertn. extract cream for facial whitening in Thais

Name: Htun, Thu Zar

Organization : Mae Fah Luang University

keyword: Facial whitening

LCSH: Cosmetics

Classification :.LCCS: WA744

LCSH: Melanins

Abstract: Background: A bright complexion is the standard of beauty in Asian cultures. Plant extracts with an inhibitory effect on melanogenesis may be a good choice of cosmetic purpose for skin whitening because of their relatively few side effects in long term application. Recently, a study showed that sacred lotus (Nelumbo nucifera Gaertn.) stamens have antityrosinase activity and inhibit melanin synthesis. However, there is no clinical study that demonstrates the efficacy of 5% Nelumbo nucifera Gaertn. extract cream for facial whitening in Thais. Objectives: To study the efficacy and satisfactory evaluation of 5% Nelumbo nucifera extract cream for facial whitening in Thais. Methods: Thirty male and female volunteers, with Fitzpatrick Skin type III-VI who matched with all including criteria were enrolled. 5% Nelumbo nucifera cream and standard cream base were applied comparatively by using block randomization in a split face design (right and left sides), two times per day for 12 weeks. Moreover, mild soaps and sunscreens were provided to the volunteers. Skin whitening was evaluated by mexameter® MX18along with photography by VISIA® analysis at baseline, 4th, 8th and 12th weeks. Satisfactory score and adverse effects were observed and recorded throughout the study. Results: 30 volunteers (age 20-60 years, mean age 34.53±9.49 years) completed the study. After 12 weeks of treatment, there was a significant melanin content reduction in lotus cream group from 323.93±41.29 (at baseline) to 273.15±34.79 (at 12th week) in forehead, 316.56±49.00 (at baseline) to 266.33±52.67 (at 12th week) in cheek and 325.88±50.41 (at baseline) to 283.20±52.56 (at 12th week) in lower face. The areas which applied 5% Nelumbo nucifera cream showed statistically significant with p value (<0.001) from 4th week of application. The dermatologists evaluated 5% Nelumbo nucifera extract cream as moderately satisfied. On the other hand, most volunteers rated 5% Nelumbo nucifera cream as much improvement. No serious side effects were found out throughout the study in both groups. Conclusion: After 12 weeks of treatment, the results of the study for lotus cream showed that there was a significant reduction in melanin content and increase in the lightness of color without serious side effects in human volunteers. Dermatologists and volunteers were also satisfied with lotus cream. Therefore, 5% Nelumbo nucifera cream is safe and effective for the use of whitening agent. However, the duration that lotus cream when will reach its maximum whitening effect and more prolonged usage complications should be studied further.

Mae Fah Luang University. The Learning Resources and Education Media Center

Address: Chiang Rai

Email: library@mfu.ac.th

Name: Rassapoom Sumaetheiwit

Role: Advisor

Created: 2016

Issued: 2560

Modified: 2020-04-29

Issued: 2017-08-30

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis WA744 H873e 2016

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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