Randomized, double-blind clinical trial for eyebrow lifting comparing between different concentration of intradermal botulinum toxin type a injection

Name: Isichon Kanrew

Organization : Mae Fah Luang University

keyword: Botulinum toxin

LCSH: Botulinum Toxins, Type A -- therapeutic use

Classification :.LCCS: WR650

LCSH: Cosmetic Techniques

LCSH: Dermatology

LCSH: Injections, Intradermal -- methods

Abstract: Background: An intradermal botulinum toxin injection is a technique of microinjections of diluted botulinum toxin to preserve facial mobility. And this technique is widely used for facelift. Between different concentration of botulinum toxin injection which one gives better result in lifting eyebrow with intradermal technique Objective: To evaluate the therapeutic result in efficacy and wrinkle at Crow’s feet, duration of action of different concentration of intradermal botulinum toxin injection in the treatment of lifting eyebrow. Material and Methods: Twenty subjects were injected single treatment with different concentration of intradermal botulinum toxin(3.0 Unit and 4.2 Unit) ,randomized, double-blind to lift eyebrow at hairline then all enrolled subjects has been measured mean brow height change and taken photograph by VISIA®, measured wrinkle at Crow’s feet by VISIOSCAN® before and after injection in each follow up visit. Clinical visits were scheduled at immediate after treatment up to 120 days. Results: there were no significant difference of brow height and the treatment of wrinkle at crow’s feet between both groups (p>0.05). However, there was significant difference in duration of action between both groups (p=0.01): The 4.2 Unit group was longer in duration than 3.0 Unit group, 91 and 68 days respectively. There was also a significant difference of subject satisfactions, they prefer 4.2 U group to 3.0 U group (p<0.05). There was no adverse side effect occurred Conclusion: In lifting eyebrow and decreasing wrinkle at Crow’s feet with intradermal injection technique, botulinum toxin type A diluted in different concentration has the same efficacy but higher concentration has longer duration of action. Both are consider safe with no side effect.

Mae Fah Luang University. The Learning Resources and Education Media Center

Address: Chiang Rai

Email: library@mfu.ac.th

Name: Thamthiwat Nararatwanchai

Role: Advisor

Created: 2016

Issued: 2560

Modified: 2020-04-29

Issued: 2017-08-28

วิทยานิพนธ์/Thesis

application/pdf

CallNumber: Thesis WR650 I862r 2016

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Dermatology

Grantor: Mae Fah Luang University

©copyrights Mae Fah Luang University

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