Kornkrit Raveevong. Effect of proprietary blend of L-arginine on metabolic syndrome parameter in person with metabolic syndrome. Master's Degree(Anti-Aging and Regenerative Science). Mae Fah Luang University . : Mae Fah Luang University , 2012.
Effect of proprietary blend of L-arginine on metabolic syndrome parameter in person with metabolic syndrome
Abstract:
Metabolic syndrome or Syndrome X composes of central obesity, high blood cholesterol and blood pressure, with the pivotal underlying state of insulin resistance. In todays world, this syndrome has a tremendous impact on a large scale of population. L-arginine is a basic natural amino acid and engaged on several metabolic pathways within the human body. It is served as a precursor for the synthesis, not only of proteins, but also of urea, polyamines, proline, glutmate, creatine and agmatine. The current interest in L-arginine is focused mainly on its close relationship with the important signal molecule nitric oxide (NO). The administration of L-arginine results in a significant improvement in endothelium-dependent dilation and positively affects the atherogenetic process. Objective: The aim of this study is to evaluate whether the long-term administration of proprietary blend of L-arginine is able to ameliorate metabolic syndrome criteria in person with metabolic syndrome compared with the placebo. Methods: We recruited 80 metabolic syndrome volunteers in this study. Each
person was given the 90 sachets of proprietary blend or placebo powder (10 g) at random to consume 1 pack every day before bedtime in all subjects for 120-day period. And, the results were collected from the blood measurement on Fasting Blood Sugar, HDL and Triglyceride. After that, the measurement was taken on the waist circumference and blood pressure at day 0, 30, 60, and 90. Results: The metabolic syndrome parameter changed in all groups. The proprietary blend group exhibited a high statistical significance in increasing the
serum HDL, reduction of the FBS, and reduction of TG. For the SBP and DBP, there was no statistical significance between the 2 groups in every interval. Conclusion: The proprietary blend of L-arginine exhibited a very promising effect in the reduction of the metabolic syndrome parameters compared to the L-arginine alone.