Pornrawee Peanpaduangrat. Efficacy and safety of fish oil in treatment of knee osteoarthritis. Master's Degree(Anti-Aging and Regenerative Medicine). Mae Fah Luang University . : Mae Fah Luang University , 2013.
Efficacy and safety of fish oil in treatment of knee osteoarthritis
Abstract:
Objective: To study efficacy and safety of fish oil in treatment of knee osteoarthritis Study design: Quasi experimental research Setting: Thammasat University hospital, Pathumthani Subject: 75 participants with primary osteoarthritis Methods: 75 participants had divided into 3 groups of 25 people to study efficacy results after take fish oil 1000mg and 2000mg once a day for 8 weeks. In 1000 mg of fish oil have EPA 400mg and DHA 200mg. All participants had complete visual analog scale
for measure knee pain, WOMAC functional subscale for assess knee function, measure 100 meters walking velocity and 3 steps walking time before take fish oil and re-measure all parameters at 8 -12 weeks after take fish oil to compare the result.
Results: The efficacy results by visual analog scale for knee pain, knee function by walking velocity on flat ground, times for go up and down 3steps stair and determine knee function by WOMAC functional subscale had compared before and after the study. All parameters had statistically significant better difference in the group of participants who had taken fish oil when compared to control group. The average score of patients satisfaction is 9.06 from 10 and also by verbal response of 50 participants everyone feel good and happy with fish oil. One participant had hematuria from silent CA bladder at 10th week but the other 49 participants were safe without any complications from fish oil. Conclusion: fish oil 1000-2000mg daily supplementation have significant efficacy to improved knee performance and also safety in mild to moderate stage of knee
osteoarthritic patients. But 2000mg of fish oil the higher dose has not significant higher efficacy than 1000mg of fish oil.